ArticleJournal of assisted reproduction and genetics2011
Biological pH buffers in IVF: help or hindrance to success.
Article in Journal of assisted reproduction and genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 110 citations in OpenAlex.
- ICSI media buffers: is there room for improvement?Journal of assisted reproduction and genetics · 2026Review
- Dynamic versus Static In Vitro Drug Release Testing of Subcutaneous Implants with Distinct Microstructures.ACS omega · 2026Article
- A comparison between the assisted reproductive technology outcomes of using two media during sperm microinjection: A bicarbonate medium (one-step) vs. a HEPES-buffered medium (SynVitro Flush).Clinical and experimental reproductive medicine · 2026Article
- Bicarbonate buffer enhances functional sperm selection compared to Zwitterionic buffers in sperm preparation.Scientific reports · 2026Article
- Ascorbic acid 2-glucoside improves survival, quality, and fertility of frozen-thawed C57Bl/6J and C57Bl/6N mouse spermatozoa.Andrology · 2025Article
- Monitoring the Dilution of Buffer Solutions with Different pH Values above and below Physiological pH in Very Small Volumes.Sensors (Basel, Switzerland) · 2024Article
- Influx of zwitterionic buffer after intracytoplasmic sperm injection (ICSI) membrane piercing alters the transcriptome of human oocytes.Journal of assisted reproduction and genetics · 2024Article
- Presence of key cholinergic enzymes in human spermatozoa and seminal fluid†.Biology of reproduction · 2024Article
- Structural Analysis of Sperm Centrioles Using N-STORM.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review.Frontiers in cardiovascular medicine · 2024Review
- The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy.Analytical and bioanalytical chemistry · 2023Article
- Biocorona on Iron Oxide Nanoparticles in a Complex Biotechnological Environment: Analysis of Proteins, Lipids, and Carbohydrates.Small science · 2023Article
- Potential effects of assisted reproductive technology on telomere length and telomerase activity in human oocytes and early embryos.Journal of ovarian research · 2023Review
- Maillard Reaction Crosslinked Alginate-Albumin Scaffolds for Enhanced Fenofibrate Delivery to the Retina: A Promising Strategy to Treat RPE-Related Dysfunction.Pharmaceutics · 2023Article
- Coping with Oxidative Stress in Reproductive Pathophysiology and Assisted Reproduction: Melatonin as an Emerging Therapeutical Tool.Antioxidants (Basel, Switzerland) · 2022Review
- Association between the morphokinetics of in-vitro-derived bovine embryos and the transcriptomic profile of the derived blastocysts.PloS one · 2022Article
- Protective Effect of Minocycline Hydrochloride on the Mouse Embryonic Development Against Suboptimal Environment.Frontiers in cell and developmental biology · 2022Article
- Protective Effect of Chlorogenic Acid on Human Sperm: In Vitro Studies and Frozen-Thawed Protocol.Antioxidants (Basel, Switzerland) · 2021Article
- Factors influencing susceptibility testing of antifungal drugs: a critical review of document M27-A4 from the Clinical and Laboratory Standards Institute (CLSI).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Review
- Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMinimizing environmental stress helps maintain cellular homeostasis and is a crucial component in optimizing embryo development in vitro and resulting ART success. One stressor of particular interest is pH. Biologic buffers, such as HEPES and MOPS, are valuable tools for stabilizing pH. The objective of this manuscript is to summarize efficacy and impact of various pH buffers used during IVF lab procedures
methodsKeyword searches were performed using Pubmed and Medline and relevant literature reviewed.
resultsVarious pH buffers have been used with varying degrees of success for gamete and embryo processing in a variety of animal species, as well as in human.
conclusionThough biologic buffers off a means to improve pH stability, not all buffers may be appropriate for use with gametes and embryos. Specific buffers may have undesired effects, and these may be buffer, species, cell type or concentration dependent. Continued research is needed to further refine and improve the use of biologic buffers for use in human ART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.