ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2012
Identification and molecular characterization of a S. agalactiae strain lacking the capsular locus.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Evidence of a novel sublineage ofMicrobial genomics · 2025Article
- Genomic characterization of group BMicrobial genomics · 2025Article
- Article
- Epidemiological Characterization of Group B Streptococcus Infections in Alberta, Canada: An Update from 2014 to 2020.Microbiology spectrum · 2021Article
- Molecular Identification of Invasive Non-typeable Group BFrontiers in cellular and infection microbiology · 2021Article
- Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets.Clinical microbiology reviews · 2018Review
- Diminished Capsule Exacerbates Virulence, Blood-Brain Barrier Penetration, Intracellular Persistence, and Antibiotic Evasion of Hyperhemolytic Group B Streptococci.The Journal of infectious diseases · 2018Article
- Article
- Identification of Group B Streptococcus Capsule Type by Use of a Dual Phenotypic/Genotypic Assay.Journal of clinical microbiology · 2017Article
- Modification of the CpsA protein reveals a role in alteration of the Streptococcus agalactiae cell envelope.Infection and immunity · 2015Article
- Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population.PloS one · 2015Article
- Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus.The Journal of biological chemistry · 2014Article
- Capsular gene typing of Streptococcus agalactiae compared to serotyping by latex agglutination.Journal of clinical microbiology · 2013Article
- Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a national surveillance program on Group B streptococci (GBS) maternal carriage and neonatal infections, a GBS strain isolated from a pregnant woman's vagino-rectal swab was non typable by either serological or molecular methods. Further molecular characterization demonstrated that the strain lacked the entire capsular locus, possibly by a recombination event that excised a 14,1 Kbase pairs genomic fragment extending from the regulatory protein cpsX gene to the neuA gene. The natural loss of the capsular locus by GBS isolated from a human has never been described so far. Such an event, while possibly a dead-end from the evolutionary point of view, leaves a still able-to-colonize organism unrecognizable by the vaccines currently under development.
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Registered trials
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