ArticleMicrobial ecology2011
Efficacy of zosteric acid sodium salt on the yeast biofilm model Candida albicans.
Article in Microbial ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Advances in Zosteric Acid: Antifouling Properties and Green Biosynthesis Toward Food Safety Applications.Foods (Basel, Switzerland) · 2026Review
- Insights on Zosteric Acid Analogues Activity Against Candida albicans Biofilm Formation.ACS omega · 2025Article
- Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Enhancing chickpea yield through the application of sulfur and sulfur-oxidizing bacteria.Scientific reports · 2025Article
- Unlocking the Antibiofilm Potential of Natural Compounds by Targeting the NADH:quinone Oxidoreductase WrbA.Antioxidants (Basel, Switzerland) · 2023Article
- Correlation between Perturbation of Redox Homeostasis and Antibiofilm Capacity of Phytochemicals at Non-Lethal Concentrations.Antioxidants (Basel, Switzerland) · 2022Review
- Metabolomic and Proteomic Changes inInternational journal of molecular sciences · 2022Article
- Sulfated phenolic acids in plants.Planta · 2022Article
- Anti-barnacle biofouling coatings for the protection of marine vessels: synthesis and progress.Environmental science and pollution research international · 2022Review
- Effects of the Quinone Oxidoreductase WrbA onAntioxidants (Basel, Switzerland) · 2021Article
- Hindering the formation and promoting the dispersion of medical biofilms: non-lethal effects of seagrass extracts.BMC complementary and alternative medicine · 2018Article
- Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candida albicans biofilm formation and hyphal growth.The Journal of antibiotics · 2017Article
- Antifouling potential of Nature-inspired sulfated compounds.Scientific reports · 2017Article
- Fungal Biofilms: Targets for the Development of Novel Strategies in Plant Disease Management.Frontiers in microbiology · 2017Article
- Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections.Antibiotics (Basel, Switzerland) · 2016Review
- Candida Biofilms: Development, Architecture, and Resistance.Microbiology spectrum · 2015Review
- Immobilized Hydrolytic Enzymes Exhibit Antibiofilm Activity Against Escherichia coli at Sub-Lethal Concentrations.Current microbiology · 2015Article
- Unravelling the Structural and Molecular Basis Responsible for the Anti-Biofilm Activity of Zosteric Acid.PloS one · 2015Article
- Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity.Molecules (Basel, Switzerland) · 2014Review
- Evaluation of zosteric acid for mitigating biofilm formation of Pseudomonas putida isolated from a membrane bioreactor system.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans is the most notorious and the most widely studied yeast biofilm former. Design of experiments (DoE) showed that 10 mg/L zosteric acid sodium salt reduced C. albicans adhesion and the subsequent biofilm formation by at least 70%, on both hydrophilic and hydrophobic surfaces of 96-well plates. Indeed, biofilm imaging revealed the dramatic impact of zosteric acid sodium salt on biofilm thickness and morphology, due to the inability of the cells to form filamentous structures while remaining metabolically active. In the same way, 10 mg/L zosteric acid sodium salt inhibited C. albicans biofilm formation when added after the adhesion phase. Contrary to zosteric acid sodium salt, methyl zosterate did not affect yeast biofilm. In addition, zosteric acid sodium salt enhanced sensitivity to chlorhexidine, chlorine, hydrogen peroxide, and cis-2-decenoic acid, with a reduction of 0.5 to 8 log units. Preliminary in vitro studies using suitable primary cell based models revealed that zosteric acid sodium salt did not compromise the cellular activity, adhesion, proliferation or morphology of either the murine fibroblast line L929 or the human osteosarcoma line MG-63. Thus the use of zosteric acid sodium salt could provide a suitable, innovative, preventive, and integrative approach to preventing yeast biofilm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.