ReviewInternational journal of molecular sciences2010
Intrinsically disordered proteins in a physics-based world.
Review in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Single-Molecule Techniques for Probing the Conformation, Dynamics and Interactions of Intrinsically Disordered Proteins.Biophysics reviews · 2025Article
- Likely Overstabilization of Charge-Charge Interactions in CHARMM36m(w): A Case for a99SB-disp Water.The journal of physical chemistry. B · 2024Article
- A generalized Kirkwood implicit solvent for the polarizable AMOEBA protein model.The Journal of chemical physics · 2023Article
- Coupled binding and folding of disordered SPIN N-terminal region in myeloperoxidase inhibition.Frontiers in molecular biosciences · 2023Article
- Toward Accurate Coarse-Grained Simulations of Disordered Proteins and Their Dynamic Interactions.Journal of chemical information and modeling · 2022Article
- Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice.Journal of fungi (Basel, Switzerland) · 2022Review
- Identification of an α-MoRF in the Intrinsically Disordered Region of the Escargot Transcription Factor.ACS omega · 2020Article
- Targeting Intrinsically Disordered Proteins through Dynamic Interactions.Biomolecules · 2020Review
- Human PCNA Structure, Function and Interactions.Biomolecules · 2020Review
- Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
- Residual Structures and Transient Long-Range Interactions of p53 Transactivation Domain: Assessment of Explicit Solvent Protein Force Fields.Journal of chemical theory and computation · 2019Article
- Residual Structure Accelerates Binding of Intrinsically Disordered ACTR by Promoting Efficient Folding upon Encounter.Journal of molecular biology · 2019Article
- HyRes: a coarse-grained model for multi-scale enhanced sampling of disordered protein conformations.Physical chemistry chemical physics : PCCP · 2017Article
- The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil.PloS one · 2017Article
- On the Helix Propensity in Generalized Born Solvent Descriptions of Modeling the Dark Proteome.Frontiers in molecular biosciences · 2017Article
- High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations.Molecular bioSystems · 2015Article
- Modulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutations.PLoS computational biology · 2015Article
- p15PAF is an intrinsically disordered protein with nonrandom structural preferences at sites of interaction with other proteins.Biophysical journal · 2014Article
- ProADD: A database on Protein Aggregation Diseases.Bioinformation · 2014Article
- Electrostatically accelerated encounter and folding for facile recognition of intrinsically disordered proteins.PLoS computational biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrinsically disordered proteins (IDPs) are a newly recognized class of functional proteins that rely on a lack of stable structure for function. They are highly prevalent in biology, play fundamental roles, and are extensively involved in human diseases. For signaling and regulation, IDPs often fold into stable structures upon binding to specific targets. The mechanisms of these coupled binding and folding processes are of significant importance because they underlie the organization of regulatory networks that dictate various aspects of cellular decision-making. This review first discusses the challenge in detailed experimental characterization of these heterogeneous and dynamics proteins and the unique and exciting opportunity for physics-based modeling to make crucial contributions, and then summarizes key lessons from recent de novo simulations of the structure and interactions of several regulatory IDPs.
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