ArticlePloS one2011
Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- GPRC5C regulates the composition of cilia in the olfactory system.BMC biology · 2023Article
- Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone.Frontiers in cell and developmental biology · 2021Article
- Potential Therapeutic Targets for Olfactory Dysfunction in Ciliopathies Beyond Single-Gene Replacement.Chemical senses · 2021Review
- Maturation of the Olfactory Sensory Neuron and Its Cilia.Chemical senses · 2020Review
- Construction and Validation of Predictive Model to Identify Critical Genes Associated with Advanced Kidney Disease.International journal of genomics · 2020Article
- Olfactory Loss and Dysfunction in Ciliopathies: Molecular Mechanisms and Potential Therapies.Current medicinal chemistry · 2019Review
- The analysis of a time-course transcriptome profile by systems biology approaches reveals key molecular processes in acute kidney injury.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice.eLife · 2017Article
- Defining an olfactory receptor function in airway smooth muscle cells.Scientific reports · 2016Article
- How does your kidney smell? Emerging roles for olfactory receptors in renal function.Pediatric nephrology (Berlin, Germany) · 2016Review
- An Olfactory Cilia Pattern in the Mammalian Nose Ensures High Sensitivity to Odors.Current biology : CB · 2015Article
- Odorant receptors regulate the final glomerular coalescence of olfactory sensory neuron axons.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development.Organogenesis · 2014Review
- General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations.Human mutation · 2013Article
- Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.PloS one · 2013Article
- Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.Neural development · 2012Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
It was reported that some proteins known to cause renal cystic disease (NPHP6; BBS1, and BBS4) also localize to the olfactory epithelium (OE), and that mutations in these proteins can cause anosmia in addition to renal cystic disease. We demonstrate here that a number of other proteins associated with renal cystic diseases - polycystin 1 and 2 (PC1, PC2), and Meckel-Gruber syndrome 1 and 3 (MKS1, MKS3) - localize to the murine OE. PC1, PC2, MKS1 and MKS3 are all detected in the OE by RT-PCR. We find that MKS3 localizes specifically to dendritic knobs of olfactory sensory neurons (OSNs), while PC1 localizes to both dendritic knobs and cilia of mature OSNs. In mice carrying mutations in MKS1, the expression of the olfactory adenylate cyclase (AC3) is substantially reduced. Moreover, in rats with renal cystic disease caused by a mutation in MKS3, the laminar organization of the OE is perturbed and there is a reduced expression of components of the odor transduction cascade (G(olf), AC3) and α-acetylated tubulin. Furthermore, we show with electron microscopy that cilia in MKS3 mutant animals do not manifest the proper microtubule architecture. Both MKS1 and MKS3 mutant animals show no obvious alterations in odor receptor expression. These data show that multiple renal cystic proteins localize to the OE, where we speculate that they work together to regulate aspects of the development, maintenance or physiological activities of cilia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.