Evidence map›Paper›PMID 21614091›Full record

ArticleNature genetics2011

Principles for the post-GWAS functional characterization of cancer risk loci.

Matthew L Freedman, Alvaro N A Monteiro, Simon A Gayther, Gerhard A Coetzee, Angela Risch, Christoph Plass, Graham Casey, Mariella De Biasi, Chris Carlson, David Duggan and 6 more

Abstract read
In one paragraph

Article in Nature genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
268citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

268 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  9. Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015
    Pooled it
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  11. Article
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  14. A review of post-GWAS studies in schizophrenia.Translational psychiatry · 2025
    Review
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208 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Matthew L FreedmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Alvaro N A Monteiro
Simon A Gayther
Gerhard A Coetzee
Angela Risch
Christoph Plass
Graham Casey
Mariella De Biasi
Chris Carlson
David Duggan
Michael James
Pengyuan Liu
Jay W Tichelaar
Haris G Vikis
Ming You
Ian G Mills

Funding

Transdisciplinary Studies of Genetic Variation in Colorectal CancerU19CA148107 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2010 to 2014
$11.1M
Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
Medical Research Council G0801875NCI NIH HHS 1U19CA148065-01NCI NIH HHS 1U19CA148107-01NCI NIH HHS 1U19CA148112-01NCI NIH HHS 1U19CA148127-01NCI NIH HHS 1U19CA148537-01NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148107NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA148537Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic VariationGenome-Wide Association StudyCatecholsGene ExpressionGenetic Predisposition to DiseaseInositolModels, BiologicalPolymorphism, Single NucleotideQuantitative Trait LociRegulatory Sequences, Nucleic AcidRiskCancellCatecholsInositol

Identifiers

PMID21614091
PMCPMC3325768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.