ArticleMolecular systems biology2011
Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- An Analytical Framework for Phenotypic Selection of Fitness-Conferring Genes.Bulletin of mathematical biology · 2026Article
- Congruence between noise and plasticity in protein expression.Scientific reports · 2025Article
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- Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics.Royal Society open science · 2020Article
- Stochastic system identification without an a priori chosen kinetic model-exploring feasible cell regulation with piecewise linear functions.NPJ systems biology and applications · 2018Article
- Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments.Journal of the Royal Society, Interface · 2017Review
- The propagation of perturbations in rewired bacterial gene networks.Nature communications · 2015Article
- An Individual-Based Diploid Model Predicts Limited Conditions Under Which Stochastic Gene Expression Becomes Advantageous.Frontiers in genetics · 2015Article
- Global coordination in adaptation to gene rewiring.Nucleic acids research · 2015Article
- Evolutionary Consequence of a Trade-Off between Growth and Maintenance along with Ribosomal Damages.PloS one · 2015Article
- Growth rate-coordinated transcriptome reorganization in bacteria.BMC genomics · 2013Article
- Multilevel comparative analysis of the contributions of genome reduction and heat shock to the Escherichia coli transcriptome.BMC genomics · 2013Article
- Systems biology: A cell in a computer.Nature · 2012Article
- Interplay between gene expression noise and regulatory network architecture.Trends in genetics : TIG · 2012Review
- Article
- Bacterial cells carrying synthetic dual-function operon survived starvation.Journal of biomedicine & biotechnology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stochastic switching is considered as a cost-saving strategy for adaptation to environmental challenges. We show here that stochastic switching of a monostable circuit can mediate the adaptation of the engineered OSU12-hisC Escherichia coli strain to histidine starvation. In this strain, the hisC gene was deleted from the His operon and placed under the control of a monostable foreign promoter. In response to histidine depletion, the OSU12-hisC population shifted to a higher HisC expression level, which is beneficial under starving conditions but is not favoured by the monostable circuit. The population shift was accompanied by growth recovery and was reversible upon histidine addition. A weak directionality in stochastic switching of hisC was observed in growing microcolonies under histidine-free conditions. Directionality and fate decision were in part dependent on the initial cellular status. Finally, microarray analysis indicated that OSU12-hisC reorganized its transcriptome to reach the appropriate physiological state upon starvation. These findings suggest that bacteria do not necessarily need to evolve signalling mechanisms to control gene expression appropriately, even for essential genes.
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