ArticleMolecular systems biology2011
Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- The Role of Intercellular Signaling in the Regulation of Bacterial Adaptive Proliferation.International journal of molecular sciences · 2023Article
- Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.Annual review of microbiology · 2022Review
- Redesigning regulatory components of quorum-sensing system for diverse metabolic control.Nature communications · 2022Article
- Article
- Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting.Frontiers in microbiology · 2022Review
- In Vitro Effect of Copper (I) Complex [Cu(NNMicroorganisms · 2021Article
- Dimension-reduction simplifies the analysis of signal crosstalk in a bacterial quorum sensing pathway.Scientific reports · 2021Article
- LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA.PLoS genetics · 2021Article
- The role of solute binding proteins in signal transduction.Computational and structural biotechnology journal · 2021Review
- Small RNA-Based Regulation of Bacterial Quorum Sensing and Biofilm Formation.Microbiology spectrum · 2018Review
- Article
- Quantifying the strength of quorum sensing crosstalk within microbial communities.PLoS computational biology · 2017Article
- Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios.Journal of bacteriology · 2017Review
- Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae.PLoS genetics · 2017Article
- Activity, Abundance, and Localization of Quorum Sensing Receptors inFrontiers in microbiology · 2017Article
- Quorum sensing signal-response systems in Gram-negative bacteria.Nature reviews. Microbiology · 2016Review
- Time-resolved proteomic analysis of quorum sensing inChemical science · 2016Article
- Social Evolution Selects for Redundancy in Bacterial Quorum Sensing.PLoS biology · 2016Article
- Antisocial luxO Mutants Provide a Stationary-Phase Survival Advantage in Vibrio fischeri ES114.Journal of bacteriology · 2015Article
- Optimal census by quorum sensing.PLoS computational biology · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Quorum sensing is a chemical signaling mechanism used by bacteria to communicate and orchestrate group behaviors. Multiple feedback loops exist in the quorum-sensing circuit of the model bacterium Vibrio harveyi. Using fluorescence microscopy of individual cells, we assayed the activity of the quorum-sensing circuit, with a focus on defining the functions of the feedback loops. We quantitatively investigated the signaling input-output relation both in cells with all feedback loops present as well as in mutants with specific feedback loops disrupted. We found that one of the feedback loops regulates receptor ratios to control the integration of multiple signals. Together, the feedback loops affect the input-output dynamic range of signal transmission and the noise in the output. We conclude that V. harveyi employs multiple feedback loops to simultaneously control quorum-sensing signal integration and to ensure signal transmission fidelity.
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