ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2011
Associations between genetic variants in vitamin D metabolism and asthma characteristics in young African Americans: a pilot study.
Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis.BMC nephrology · 2020Pooled it
- Pooled it
- Effect of vitamin D supplementation on moderate to severe bronchial asthma.Indian journal of pediatrics · 2014Trial
- Genetic and serum biomarkers of NSAID hypersensitivity reactions.Frontiers in pharmacology · 2025Article
- Genetic Diversity in Bronchial Asthma Susceptibility: Exploring the Role of Vitamin D Receptor Gene Polymorphisms in Varied Geographic Contexts.International journal of molecular sciences · 2024Article
- Review
- Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.Biomedicines · 2022Review
- Meta-Analysis of Vitamin D Receptor Gene Polymorphisms in Childhood Asthma.Frontiers in pediatrics · 2022Article
- Association of vitamin D gene polymorphisms in children with asthma - A systematic review.Heliyon · 2020Review
- Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis.The Journal of clinical endocrinology and metabolism · 2020Article
- The Vitamin D Receptor Gene Polymorphisms in Asthmatic Children: A Case-Control Study.Pediatric allergy, immunology, and pulmonology · 2019Article
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- CYP27A1, CYP24A1, and RXR-α Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study.Journal of molecular neuroscience : MN · 2018Article
- The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections.PloS one · 2017Article
- Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China.BMC genetics · 2016Article
- The impact of vitamin D on asthmatic human airway smooth muscle.Expert review of respiratory medicine · 2016Article
- Genetic associations with viral respiratory illnesses and asthma control in children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy in Cypriot adolescents: a case-control study.Multidisciplinary respiratory medicine · 2015Article
- Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans.Human genetics · 2014Article
- Effect of vitamin D-binding protein genotype on the development of asthma in children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
introductionLow vitamin D levels have been associated with asthma severity in children. Young, urban African Americans (AAs) have high rates of hypovitaminosis D and asthma. Our objective was to determine associations between variants in vitamin D metabolism genes and asthma characteristics in a pilot study of young urban AAs. MATERIALS AND
methodsTwo urban AA cohorts of subjects aged 6 to 20 years (139 subjects with asthma and 74 subjects without asthma) were genotyped for 12 single nucleotide polymorphisms (SNPs) in 3 vitamin D metabolism genes: VDR (vitamin D receptor), CYP24A1 (cytochrome P450 vitamin D 24-hydroxylase), and CYP2R1 (cytochrome P450 vitamin D 25-hydroxylase). In a case-control analysis, SNPs were studied for associations with an asthma diagnosis. Within the asthmatic cohort, SNPs were analyzed for associations with quantitative asthma characteristics. All analyses were adjusted for age, sex, and body mass index percentile.
resultsOnly the CYP2R1 SNP rs10766197 homozygous minor genotype was associated with asthma (P = 0.044). CYP24A1 SNP rs2248137 was associated with lower vitamin D levels (P = 0.006). Within the asthma cohort, multiple significant associations between SNPs and asthma characteristics were identified; VDR SNP rs2228570 was associated with the higher nighttime asthma morbidity scores (P = 0.04), lower baseline spirometric measures (P < 0.05), 1 or more positive aeroallergen skin test (P = 0.003), and increased immunoglobulin E levels (P < 0.001). DISCUSSION: This pilot study demonstrates that variants in vitamin D metabolism genes are associated with quantitative asthma characteristics in young, urban AAs. The collection of these associations provides evidence for the need for a large population-based study of vitamin D-relevant SNPs in this cohort.
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Registered trials
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