ArticleAmerican journal of physiology. Cell physiology2011
Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract.
Article in American journal of physiology. Cell physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- DMV extrasynaptic NMDA receptors regulate caloric intake in rats.JCI insight · 2021Article
- Swallow Motor Pattern Is Modulated by Fixed or Stochastic Alterations in Afferent Feedback.Frontiers in human neuroscience · 2020Article
- Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract.International journal of molecular sciences · 2019Article
- Effects of acute and chronic nicotine on catecholamine neurons of the nucleus of the solitary tract.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Central Respiration and Mechanical Ventilation in the Gating of Swallow With Breathing.Frontiers in physiology · 2018Article
- Boosting Endogenous Resistance of Brain to Ischemia.Molecular neurobiology · 2017Article
- Nicotine enhances inhibition of mouse vagal motor neurons by modulating excitability of premotor GABAergic neurons in the nucleus tractus solitarii.Journal of neurophysiology · 2015Article
- Article
- Presynaptic T-type Ca2+ channels modulate dendrodendritic mitral-mitral and mitral-periglomerular connections in mouse olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The mechanism of choline-mediated inhibition of acetylcholine release in mouse motor synapses.Acta naturae · 2014Article
- Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability.Neuropharmacology · 2014Review
- Article
- The role of the glucocorticoids in developing resilience to stress and addiction.Frontiers in psychiatry · 2013Article
- Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target.Journal of neurophysiology · 2012Article
- Somatic integration of single ion channel responses of α7 nicotinic acetylcholine receptors enhanced by PNU-120596.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The nucleus of the solitary tract (NTS) is the principal integrating relay in the processing of visceral sensory information. Functional nicotinic acetylcholine receptors (nAChRs) have been found on presynaptic glutamatergic terminals in subsets of caudal NTS neurons. Activation of these receptors has been shown to enhance synaptic release of glutamate and thus may modulate autonomic sensory-motor integration and visceral reflexes. However, the mechanisms of nAChR-mediated facilitation of synaptic glutamate release in the caudal NTS remain elusive. This study uses rat horizontal brainstem slices, patch-clamp electrophysiology, and fluorescent Ca(2+) imaging to test the hypothesis that a direct Ca(2+) entrance into glutamatergic terminals through active presynaptic non-α7- or α7-nAChR-mediated ion channels is sufficient to trigger synaptic glutamate release in subsets of caudal NTS neurons. The results of this study demonstrate that, in the continuous presence of 0.3 μM tetrodotoxin, a selective blocker of voltage-activated Na(+) ion channels, facilitation of synaptic glutamate release by activation of presynaptic nAChRs (detected as an increase in the frequency of miniature excitatory postsynaptic currents) requires external Ca(2+) but does not require activation of presynaptic Ca(2+) stores and presynaptic high- and low-threshold voltage-activated Ca(2+) ion channels. Expanding the knowledge of mechanisms and pharmacology of nAChRs in the caudal NTS should benefit therapeutic approaches aimed at restoring impaired autonomic homeostasis.
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