ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The pattern of glomerular map formation defines responsiveness to aversive odorants in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- Kirrel3 homophilic adhesion function is required for male-directed aggression and vomeronasal acuity to urine chemosignals.Frontiers in cellular neuroscience · 2026Article
- Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium.Development, growth & differentiation · 2025Article
- Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects.Frontiers in cell and developmental biology · 2024Article
- Article
- Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing.Nature neuroscience · 2022Article
- The role of the odorant receptors in the formation of the sensory map.BMC biology · 2021Review
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Coordination of olfactory receptor choice with guidance receptor expression and function in olfactory sensory neurons.PLoS genetics · 2018Article
- Structural Features of an OR37 Glomerulus: A Comparative Study.Frontiers in neuroanatomy · 2017Article
- Role of Rb during Neurogenesis and Axonal Guidance in the Developing Olfactory System.Frontiers in molecular neuroscience · 2016Article
- Neural map formation and sensory coding in the vomeronasal system.Cellular and molecular life sciences : CMLS · 2015Review
- The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Segregated labeling of olfactory bulb projection neurons based on their birthdates.The European journal of neuroscience · 2015Article
- Olfactory systems and neural circuits that modulate predator odor fear.Frontiers in behavioral neuroscience · 2014Review
- Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression.Development (Cambridge, England) · 2013Article
- Ominous odors: olfactory control of instinctive fear and aggression in mice.Current opinion in neurobiology · 2013Review
- Critical role of GFRα1 in the development and function of the main olfactory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.Neural development · 2012Article
- Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons.Development (Cambridge, England) · 2012Article
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4 authors.
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Abstract
In many species, the detection and recognition of odors is critical to regulate behaviors that are essential for survival, such as foraging for food and avoidance of predators. The formation of complex stereotypic connections between olfactory sensory neurons (OSNs) and second-order neurons in the olfactory bulb (OB) is believed to be important for accurate odorant information processing. In mice, ablation of OSNs that innervate the dorsal region of the OB leads to a loss of avoidance behavior in response to aversive and predator odorants (Kobayakawa et al., 2007). It remains to be determined whether the accurate formation of a glomerular map in this region of the OB is required for these innate responses. Here, we have generated mice that lack expression of the axon guidance receptor Robo-2 in OSNs and found that ablation of Robo-2 expression leads to mistargeting of subsets of OSN axons within the dorsal region of the OB. Furthermore, these mice show decreased avoidance behavior toward the predator odorant trimethyl-thiazoline. Our results indicate that the pattern of glomerular innervation in the OB is critical for innate behavioral responses in mice.
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