Evidence map›Paper›PMID 21613460›Full record

ArticleClinical and vaccine immunology : CVI2011

Improved specificity of a multiplex immunoassay for quantitation of anti-diphtheria toxin antibodies with the use of diphtheria toxoid.

Pieter G M van Gageldonk, Christina von Hunolstein, Fiona R M van der Klis, Guy A M Berbers

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Maternal and infant immunity againstEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Observational
  3. Article
  4. Validation of a diphtheria toxoid multiplex bead assay for serosurveys.Diagnostic microbiology and infectious disease · 2021
    Article
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  14. Comparison of seven commercial enzyme-linked immunosorbent assays for the detection of anti-diphtheria toxin antibodies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Pieter G M van GageldonkLaboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment, Bilthoven, Netherlands. Pieter.van.gageldonk@rivm.nl
Christina von Hunolstein
Fiona R M van der Klis
Guy A M Berbers
National Institute for Public Health and the Environment · NLIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A nonspecific binding of antibodies to diphtheria toxin, especially in adult serum samples, was observed in our diphtheria-tetanus-pertussis multiplex immunoassay (DTaP4 MIA). This can be significantly reduced by the use of diphtheria toxoid, achieving a good correlation with the Vero cell neutralization test and the toxin binding inhibition assay.

Indexed as

Antibodies, BacterialCorynebacterium diphtheriaeDiphtheria-Tetanus-Pertussis VaccineDiphtheria ToxoidHumansImmunoassayMethodsProtein BindingSensitivity and SpecificityAntibodies, BacterialDiphtheria-Tetanus-Pertussis VaccineDiphtheria Toxoid

Identifiers

PMID21613460
PMCPMC3147321
OpenAlexW2100650548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.