Evidence map›Paper›PMID 21613433›Full record

ArticleJournal of clinical microbiology2011

Interleukin-28B genotyping by melt-mismatch amplification mutation assay PCR analysis using single nucleotide polymorphisms rs12979860 and rs8099917, a useful tool for prediction of therapy response in hepatitis C patients.

Salvador Fonseca-Coronado, Gilberto Vaughan, Mayra Yolanda Cruz-Rivera, Juan Carlos Carpio-Pedroza, Karina Ruiz-Tovar, Juan Alberto Ruiz-Pacheco, Alejandro Escobar-Gutiérrez

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  8. Review
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  10. Article
  11. Allele-specific PCR for determination of IL28B genotype.Journal of clinical microbiology · 2012
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Salvador Fonseca-CoronadoUnidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Gilberto Vaughan
Mayra Yolanda Cruz-Rivera
Juan Carlos Carpio-Pedroza
Karina Ruiz-Tovar
Juan Alberto Ruiz-Pacheco
Alejandro Escobar-Gutiérrez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have identified associations between single nucleotide polymorphisms (SNPs) occurring near the interleukin-28B (IL-28B) gene and response to antiviral treatment among hepatitis C virus (HCV) patients. Here, we describe a reliable melt-mismatch amplification mutation assay (melt-MAMA) PCR-based genotyping method for IL-28B which can be used in the management of HCV patients, helping to better define the course of therapy.

Indexed as

MutationPolymorphism, Single NucleotideTransition TemperatureAgedAntiviral AgentsFemaleGenotypeHepatitis C, ChronicHumansInterferon LambdaInterferonsInterleukinsMaleMiddle AgedPolymerase Chain ReactionPrognosisAntiviral AgentsInterferon Lambdainterferon-lambda, humanInterferonsInterleukins

Identifiers

PMID21613433
PMCPMC3147879

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.