ArticleSchizophrenia bulletin2013
Lack of gender influence on cortical and subcortical gray matter development in childhood-onset schizophrenia.
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis.Neuromolecular medicine · 2023Pooled it
- Sex differences in brain structures throughout the lifetime.Aging brain · 2023Article
- Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients.Translational psychiatry · 2020Article
- Sex differences in the developing brain: insights from multimodal neuroimaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Lack of Gender-Related Differences in Childhood-Onset Schizophrenia.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Gender effects on brain changes in early-onset psychosis.European child & adolescent psychiatry · 2015Article
- Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis.Expert review of neurotherapeutics · 2013Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProgressive cortical gray matter (GM) abnormalities are an established feature of schizophrenia and are more pronounced in rare, severe, and treatment refractory childhood-onset schizophrenia (COS) cases. The effect of sex on brain development in schizophrenia is poorly understood and studies to date have produced inconsistent results.
methodsUsing the largest to date longitudinal sample of COS cases (n = 104, scans = 249, Male/Female [M/F] = 57/47), we compared COS sex differences with sex differences in a sample of matched typically developing children (n = 104, scans = 244, M/F = 57/47), to determine whether or not sex had differential effects on cortical and subcortical brain development in COS.
resultsOur results showed no significant differential sex effects in COS for either GM cortical thickness or subcortical volume development (sex × diagnosis × age interaction; false discovery rate q = 0.05).
conclusionSex appears to play a similar role in cortical and subcortical GM development in COS as it does in normally developing children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.