ArticleThe Journal of heredity
Haplotype-based genomic sequencing of a chromosomal polymorphism in the white-throated sparrow (Zonotrichia albicollis).
Article in The Journal of heredity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Massive Genomic and Transcriptomic Changes Within a Young Inversion Polymorphism in the Absence of Degeneration.Molecular ecology · 2026Article
- Allele-specific cis-regulatory methylation of the gene for vasoactive intestinal peptide in white-throated sparrows.Genes, brain, and behavior · 2022Article
- Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows.eLife · 2022Article
- Supergenes on steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Vasoactive intestinal peptide as a mediator of the effects of a supergene on social behaviour.Proceedings. Biological sciences · 2020Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism.Hormones and behavior · 2018Article
- Polymorphisms in sex steroid receptors: From gene sequence to behavior.Frontiers in neuroendocrinology · 2017Review
- Divergence and Functional Degradation of a Sex Chromosome-like Supergene.Current biology : CB · 2016Article
- Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.Genes, brain, and behavior · 2015Article
- Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs.Integrative and comparative biology · 2015Review
- Adaptive divergence in the monkey flower Mimulus guttatus is maintained by a chromosomal inversion.Evolution; international journal of organic evolution · 2015Article
- Evolution of dominance mechanisms at a butterfly mimicry supergene.Nature communications · 2014Article
- Supergenes and their role in evolution.Heredity · 2014Review
- New insights into the hormonal and behavioural correlates of polymorphism in white-throated sparrows,Animal behaviour · 2014Article
- Hormonal regulation of vasotocin receptor mRNA in a seasonally breeding songbird.Hormones and behavior · 2014Article
- Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Polyandry and alternative mating tactics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
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Authors and funding
8 authors.
Funding
Abstract
Inversion polymorphisms have been linked to a variety of fundamental biological and evolutionary processes. Yet few studies have used large-scale genomic sequencing to directly compare the haplotypes associated with the standard and inverted chromosome arrangements. Here we describe the targeted genomic sequencing and comparison of haplotypes representing alternative arrangements of a common inversion polymorphism linked to a suite of phenotypes in the white-throated sparrow (Zonotrichia albicollis). More than 7.4 Mb of genomic sequence was generated and assembled from both the standard (ZAL2) and inverted (ZAL2(m)) arrangements. Sequencing of a pair of inversion breakpoints led to the identification of a ZAL2-specific segmental duplication, as well as evidence of breakpoint reusage. Comparison of the haplotype-based sequence assemblies revealed low genetic differentiation outside versus inside the inversion indicative of historical patterns of gene flow and suppressed recombination between ZAL2 and ZAL2(m). Finally, despite ZAL2(m) being maintained in a near constant state of heterozygosity, no signatures of genetic degeneration were detected on this chromosome. Overall, these results provide important insights into the genomic attributes of an inversion polymorphism linked to mate choice and variation in social behavior.
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