ArticleInvestigative ophthalmology & visual science2011
Calpain inhibition attenuates apoptosis of retinal ganglion cells in acute optic neuritis.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models.Neurochemistry international · 2024Article
- Review
- Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2021Article
- Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons.Frontiers in cell and developmental biology · 2021Review
- Cytokine/chemokine dysregulation in progressive MS patient is apparent and can be modulated by calpain inhibition.Metabolic brain disease · 2020Article
- CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.Human mutation · 2019Article
- Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner.Journal of neuroinflammation · 2017Article
- Celastrol Attenuates Multiple Sclerosis and Optic Neuritis in an Experimental Autoimmune Encephalomyelitis Model.Frontiers in pharmacology · 2017Article
- Retinal Cell Degeneration in Animal Models.International journal of molecular sciences · 2016Review
- CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model.Human molecular genetics · 2015Article
- Role of Protease-Inhibitors in Ocular Diseases.Molecules (Basel, Switzerland) · 2014Review
- Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis.Journal of neurochemistry · 2014Article
- Control of photoreceptor autophagy after retinal detachment: the switch from survival to death.Investigative ophthalmology & visual science · 2014Article
- Displaced retinal ganglion cells in albino and pigmented rats.Frontiers in neuroanatomy · 2014Article
- Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats.Journal of neurochemistry · 2013Article
- Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeOptic neuritis (ON), inflammation of the optic nerve, is strongly associated with the pathogenesis of multiple sclerosis (MS) and is initiated by the attack of autoreactive T cells against self-myelin antigens, resulting in demyelination, degeneration of retinal ganglion cells (RGCs), and cumulative visual impairment.
methodsExperimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats on day 0, and animals received daily intraperitoneal injections of calpain inhibitor (calpeptin) or vehicle from day 1 until killed. Retinal cell death was analyzed by DNA fragmentation, and surviving ganglion cells were quantified after double labeling of retinal tissue with TUNEL and Brn3a. The expression of apoptotic and inflammatory proteins was determined by Western blotting.
resultsIt was demonstrated that calpain inhibition downregulates expression of proapoptotic proteins and the proinflammatory molecule nuclear factor-kappa B (NF-κB) in the retina of Lewis rats with acute EAE. Immunofluorescent labeling revealed that apoptotic cells in the RGC layer of vehicle-treated EAE animals were Brn3a positive, and a moderate dose of calpeptin dramatically reduced the frequency of apoptotic RGCs.
conclusionsThese results suggest that calpain inhibition might be a useful supplement to immunomodulatory therapies such as corticosteroids in ON, due to its neuroprotective effect on RGCs.
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