Trial reportThe Journal of clinical endocrinology and metabolism2011
Short-term plasticity of gray matter associated with leptin deficiency and replacement.
Trial report in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of leptin deficiency and replacement on cerebellar response to food-related cues.Cerebellum (London, England) · 2013Trial
- Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions.Endocrine connections · 2025Review
- Cerebellocerebral connectivity predicts body mass index: a new open-source Python-based framework for connectome-based predictive modeling.GigaScience · 2025Article
- Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications.Biomedicines · 2024Review
- Leptin's Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Effect of acute and long-term exercise on leptin levels in depressed outpatients.BMC public health · 2023Article
- Differential impact of body mass index and leptin on baseline and longitudinal positron emission tomography measurements of the cerebral metabolic rate for glucose in amnestic mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
- Article
- Ciliary neurotrophic factor signaling in the rat orbitofrontal cortex ameliorates stress-induced deficits in reversal learning.Neuropharmacology · 2019Article
- The Complex Interactions Between Obesity, Metabolism and the Brain.Frontiers in neuroscience · 2019Review
- Leptin in depression: a potential therapeutic target.Cell death & disease · 2018Review
- Impact of leptin on memory function and hippocampal structure in mild cognitive impairment.Human brain mapping · 2016Article
- Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity.The European journal of neuroscience · 2016Article
- The Effects of Leptin Replacement on Neural Plasticity.Neural plasticity · 2016Review
- Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism.Metabolism: clinical and experimental · 2015Review
- Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure.The Journal of clinical endocrinology and metabolism · 2014Article
- Plasma leptin concentrations are highly correlated to emotional states throughout the day.Translational psychiatry · 2014Article
- The Cerebellum and Premenstrual Dysphoric Disorder.AIMS neuroscience · 2014Article
- Review
- Food for thought: the role of appetitive peptides in age-related cognitive decline.Ageing research reviews · 2013Review
Corrections and comments
- Erratum issuedDosage error in article text
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
contextLeptin affects neurogenesis, neuronal growth, and viability. We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake.
objectiveThe aim of this study was to report the changes in brain structure at different states of leptin supplementation.
designWe conducted a nonrandomized trial. SETTING AND PATIENTS: We studied three adults with congenital leptin deficiency due to a mutation in the leptin gene.
interventionPatients received treatment with recombinant methionyl human leptin, with annual 11- to 36-d periods of treatment withholding followed by treatment restoration over 3 yr.
main outcome measuresGM concentration (by voxel-based morphometry analysis of magnetic resonance scans) was correlated with body mass index (BMI) and leptin supplementation.
resultsAnnually withholding leptin supplementation for several weeks increased BMI and reversed the original effects of leptin in the cerebellum and ACG. The changes in the ACG were consistent with an indirect effect of leptin mediated through increased BMI. In the cerebellum, where leptin receptors are most dense, GM changes appeared to be direct effects of leptin. Leptin restoration did not lead to recovery of GM in the short term but did lead to an unexpected GM increase in the posterior half of the left thalamus, particularly the pulvinar nucleus.
conclusionThese findings provide the first in vivo evidence of remarkably plastic, reversible, and regionally specific effects of leptin on human brain morphology. They suggest that leptin may have therapeutic value in modulating plasticity-dependent brain functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.