ArticleDevelopment (Cambridge, England)2011
Scaling of the Bicoid morphogen gradient by a volume-dependent production rate.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Shared candidate genes associated with variation in egg size in cold-adapted and artificially selected Drosophila melanogaster.Developmental biology · 2026Article
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Embryonic scaling: morphogen gradients, size sensing, and scaler genes.Frontiers in cell and developmental biology · 2026Review
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Precise and scalable self-organization in mammalian pseudo-embryos.Nature structural & molecular biology · 2024Article
- Rapid response of fly populations to gene dosage across development and generations.Nature communications · 2024Article
- Article
- Size regulation of the lateral organ initiation zone and its role in determining cotyledon number in conifers.Frontiers in plant science · 2023Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Dynamic patterning by morphogens illuminated by cis-regulatory studies.Development (Cambridge, England) · 2021Review
- Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors.Developmental cell · 2020Article
- Article
- Scale invariance of BMP signaling gradients in zebrafish.Scientific reports · 2019Article
- Two-Exponential Models of Gene Expression Patterns for Noisy Experimental Data.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- Scale-invariant patterning by size-dependent inhibition of Nodal signalling.Nature cell biology · 2018Article
- Mechanisms and Measurements of Scale Invariance of Morphogen Gradients.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important feature of development is the formation of patterns that are proportional to the overall size of the embryo. But how such proportionality, or scaling, is achieved mechanistically remains poorly understood. Furthermore, it is currently unclear whether organisms utilize similar or distinct mechanisms to achieve scaling within a species and between species. Here we investigate within-species scaling mechanisms for anterior-posterior (A-P) patterning in Drosophila melanogaster, focusing specifically on the properties of the Bicoid (Bcd) morphogen gradient. Using embryos from lines artificially selected for large and small egg volume, we show that large embryos have higher nuclear Bcd concentrations in the anterior than small embryos. This anterior difference leads to scaling properties of the Bcd gradient profiles: in broad regions of the large and small embryos along the A-P axis, normalizing their positions to embryo length reduces the differences in both the nuclear Bcd concentrations and Bcd-encoded positional information. We further trace the origin of Bcd gradient scaling by showing directly that large embryos have more maternally deposited bcd mRNA than small embryos. Our results suggest a simple model for how within-species Bcd gradient scaling can be achieved. In this model, the Bcd production rate, which is dependent on the total number of bcd mRNA molecules in the anterior, is scaled with embryo volume.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.