ArticleDevelopment (Cambridge, England)2011
Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Guidelines and definitions for research on epithelial-mesenchymal transition.Nature reviews. Molecular cell biology · 2020Guideline
- Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Cytoneme feedback ensures signaling specificity when multiple ligands converge on a common receptor.bioRxiv : the preprint server for biology · 2025Article
- The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023Review
- NaNuTrap: a technique for in vivo cell nucleus labelling using nanobodies.Development (Cambridge, England) · 2021Article
- FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity.Current biology : CB · 2020Article
- Collective Migrations ofGenetics · 2020Review
- The Physical Mechanisms ofGenetics · 2020Article
- Sticking to a plan: adhesion and signaling control spatial organization of cells within migrating collectives.Current opinion in genetics & development · 2019Review
- The endoderm: a divergent cell lineage with many commonalities.Development (Cambridge, England) · 2019Review
- Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis.Current opinion in cell biology · 2018Review
- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
- CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.PLoS genetics · 2016Article
- Abl suppresses cell extrusion and intercalation during epithelium folding.Molecular biology of the cell · 2016Article
- The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development.Developmental cell · 2016Article
- The Formin Diaphanous Regulates Myoblast Fusion through Actin Polymerization and Arp2/3 Regulation.PLoS genetics · 2015Article
- Ectopic expression screen identifies genes affecting Drosophila mesoderm development including the HSPG Trol.G3 (Bethesda, Md.) · 2014Article
- SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling.Developmental cell · 2014Article
- Cell intercalation from top to bottom.Nature reviews. Molecular cell biology · 2014Review
- Two-photon imaging of multiple fluorescent proteins by phase-shaping and linear unmixing with a single broadband laser.Optics express · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Fibroblast growth factor (FGF)-dependent epithelial-mesenchymal transitions and cell migration contribute to the establishment of germ layers in vertebrates and other animals, but a comprehensive demonstration of the cellular activities that FGF controls to mediate these events has not been provided for any system. The establishment of the Drosophila mesoderm layer from an epithelial primordium involves a transition to a mesenchymal state and the dispersal of cells away from the site of internalisation in a FGF-dependent fashion. We show here that FGF plays multiple roles at successive stages of mesoderm morphogenesis in Drosophila. It is first required for the mesoderm primordium to lose its epithelial polarity. An intimate, FGF-dependent contact is established and maintained between the germ layers through mesoderm cell protrusions. These protrusions extend deep into the underlying ectoderm epithelium and are associated with high levels of E-cadherin at the germ layer interface. Finally, FGF directs distinct hitherto unrecognised and partially redundant protrusive behaviours during later mesoderm spreading. Cells first move radially towards the ectoderm, and then switch to a dorsally directed movement across its surface. We show that both movements are important for layer formation and present evidence suggesting that they are controlled by genetically distinct mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.