ArticleBMC evolutionary biology2011
Reduced MHC and neutral variation in the Galápagos hawk, an island endemic.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 30 citations in OpenAlex.
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- Comparing Class II MHC DRB3 Diversity in Colombian Simmental and Simbrah Cattle Across Worldwide Bovine Populations.Frontiers in genetics · 2022Article
- Allelic diversity and selection at the MHC class I and class II in a bottlenecked bird of prey, the White-tailed Eagle.BMC evolutionary biology · 2019Article
- Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations.Frontiers in genetics · 2019Article
- Diversity of MHC class I alleles in Spheniscus humboldti.Immunogenetics · 2017Article
- Polymorphism in the major histocompatibility complex (MHC class II B) genes of the Rufous-backed Bunting (PeerJ · 2017Article
- The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana).Primates; journal of primatology · 2016Article
- High major histocompatibility complex class I polymorphism despite bottlenecks in wild and domesticated populations of the zebra finch (Taeniopygia guttata).BMC evolutionary biology · 2015Article
- Characterization of a non-classical MHC class II gene in the vulnerable Chinese egret (Egretta eulophotes).Immunogenetics · 2015Article
- 454 screening of individual MHC variation in an endemic island passerine.Immunogenetics · 2015Article
- Birds are islands for parasites.Biology letters · 2014Article
- Combining molecular evolution and environmental genomics to unravel adaptive processes of MHC class IIB diversity in European minnows (Phoxinus phoxinus).Ecology and evolution · 2013Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenes at the major histocompatibility complex (MHC) are known for high levels of polymorphism maintained by balancing selection. In small or bottlenecked populations, however, genetic drift may be strong enough to overwhelm the effect of balancing selection, resulting in reduced MHC variability. In this study we investigated MHC evolution in two recently diverged bird species: the endemic Galápagos hawk (Buteo galapagoensis), which occurs in small, isolated island populations, and its widespread mainland relative, the Swainson's hawk (B. swainsoni).
resultsWe amplified at least two MHC class II B gene copies in each species. We recovered only three different sequences from 32 Galápagos hawks, while we amplified 20 unique sequences in 20 Swainson's hawks. Most of the sequences clustered into two groups in a phylogenetic network, with one group likely representing pseudogenes or nonclassical loci. Neutral genetic diversity at 17 microsatellite loci was also reduced in the Galápagos hawk compared to the Swainson's hawk.
conclusionsThe corresponding loss in neutral diversity suggests that the reduced variability present at Galápagos hawk MHC class II B genes compared to the Swainson's hawk is primarily due to a founder event followed by ongoing genetic drift in small populations. However, purifying selection could also explain the low number of MHC alleles present. This lack of variation at genes involved in the adaptive immune response could be cause for concern should novel diseases reach the archipelago.
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