ArticleJournal of neurotrauma2011
Modulation of ischemia-induced NMDAR1 activation by environmental enrichment decreases oxidative damage.
Article in Journal of neurotrauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Neuroprotective and therapeutic effect ofSaudi journal of biological sciences · 2019Article
- Exercising New Neurons to Vanquish Alzheimer Disease.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions.Current neuropharmacology · 2018Review
- Combining the Antipsychotic Drug Haloperidol and Environmental Enrichment after Traumatic Brain Injury Is a Double-Edged Sword.Journal of neurotrauma · 2017Article
- Altered Levels of Zinc and N-methyl-D-aspartic Acid Receptor Underlying Multiple Organ Dysfunctions After Severe Trauma.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling.Neuropathology and applied neurobiology · 2015Article
- Retracted: Involvement of insulin-like growth factor-1 in chemotherapy-related cognitive impairment.Behavioural brain research · 2015Article
- Blood-brain barrier dysfunction in disorders of the developing brain.Frontiers in neuroscience · 2015Review
- Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling.Journal of neuroinflammation · 2014Article
- The impact of microglial activation on blood-brain barrier in brain diseases.Frontiers in cellular neuroscience · 2014Review
- Dysregulation in myelination mediated by persistent neuroinflammation: possible mechanisms in chemotherapy-related cognitive impairment.Brain, behavior, and immunity · 2014Article
- Noninvasive strategies to promote functional recovery after stroke.Neural plasticity · 2013Review
- Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus.Brain, behavior, and immunity · 2012Article
- Association between long-term cognitive decline in Vietnam veterans with TBI and caregiver attachment style.The Journal of head trauma rehabilitationObservational
Corrections and comments
- Retraction · 2015-05-27Duplication of/in Image · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Misconduct by Author ·
- Commented on by
- Commented on by
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In this study, we examined whether enriched environment (EE) housing has direct neuroprotective effects on oxidative damage following transient global cerebral ischemia. Fifty-two adult male Wistar rats were included in the study and received either ischemia or sham surgery. Once fully awake, rats in each group were randomly assigned to either: EE housing or socially paired housing (CON). Animals remained in their assigned environment for 7 days, and then were killed. Our data showed that glutamate receptor expression was significantly higher in the hippocampus of the ischemia CON group than in the ischemia EE group. Furthermore, the oxidative DNA damage, protein oxidation, and neurodegeneration in the hippocampus of the ischemia CON group were significantly increased compared to the ischemia EE group. These results suggest that EE housing possibly modulated the ischemia-induced glutamate excitotoxicity, which then attenuated the oxidative damage and neurodegeneration in the ischemia EE rats.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.