ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2011
Arterial stiffness: from physiology to clinical implications.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Functional vascular study in hypertensive subjects with type 2 diabetes using losartan or amlodipine.Arquivos brasileiros de cardiologia · 2014Trial
- Effect of perindopril on pulse-wave velocity and endothelin-1 in black hypertensive patients.Cardiovascular journal of Africa · 2012Trial
- A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis.Annals of medicine · 2025Article
- Analysis of the Sex-Specific Risk Factors for Arterial Stiffness.Reviews in cardiovascular medicine · 2025Article
- Saturation effect of brachial-ankle pulse wave velocity on first stroke in adults with hypertension: a prospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview.Life (Basel, Switzerland) · 2024Review
- Validation of an early vascular aging construct model for comprehensive cardiovascular risk assessment using external risk indicators for improved clinical utility: data from the EVasCu study.Cardiovascular diabetology · 2024Article
- Stem Cell Based Approaches to Modulate the Matrix Milieu in Vascular Disorders.Frontiers in cardiovascular medicine · 2022Review
- Predictors of Arterial Stiffness Amongst the 24-Hour Ambulatory Blood Pressure Variables in Hypertensive Patients.Cureus · 2020Article
- Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys.American journal of physiology. Heart and circulatory physiology · 2020Article
- Myocardial Contractility: Historical and Contemporary Considerations.Frontiers in physiology · 2020Article
- Article
- Evaluation of aortic stiffness by a new simplified 2D speckle tracking analysis.The international journal of cardiovascular imaging · 2018Article
- Long-term improvement of arterial wall characteristics in patients with diabetes mellitus type 1 using cyclic, intermittent treatment with a low-dose fluvastatin and valsartan combination.Experimental and therapeutic medicine · 2015Article
- Use of ambulatory blood pressure monitoring to guide hypertensive therapy.Current treatment options in cardiovascular medicine · 2013Article
- The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness.Frontiers in endocrinology · 2013Review
- Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system.Frontiers in physiology · 2013Article
- Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults.Pulmonary medicine · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current European guidelines for the management of arterial hypertension introduce the assessment of arterial stiffness by pulse wave velocity (PWV) as an index of hypertension-related cardiovascular target organ damage. An increase in arterial stiffness is related to haemodynamic modifications at the level of the aorta, leading to a rise in cardiac afterload, a reduction in coronary perfusion and an overstretch of the aortic walls. An increasing number of studies have demonstrated the accuracy of PWV as an independent predictor of cardiovascular events and cardiovascular mortality in patients with different co-morbidities and cardiovascular risk. Many strategies have demonstrated their efficacy in preventing arterial stiffening; therapy of arterial hypertension is the mainstay in the management of patients with increased PWV and altered pulse wave reflection. Literature has clearly shown the specific efficacy of drugs interfering with the renin-angiotensin-aldosterone system and calcium-channel blockers in the control of central haemodynamics, particularly when compared with β-blockers (β-adrenoceptor antagonists). The same action has not yet been demonstrated on PWV. Further studies are needed to assess the real relative efficacy of different drug classes on the management of arterial stiffness and the clinical and prognostic relevance of these therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.