Evidence map›Paper›PMID 21611972›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011

Areal and volumetric bone mineral density and geometry at two levels of protein intake during caloric restriction: a randomized, controlled trial.

Deeptha Sukumar, Hasina Ambia-Sobhan, Robert Zurfluh, Yvette Schlussel, Theodore J Stahl, Chris L Gordon, Sue A Shapses

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 9 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00472680 naterminatednot on this map

Nutritional Regulation of Bone - Aim 2

TypeinterventionalSponsorRutgers UniversityRan2010 to 2016Enrolled5ConditionsWeight LossArmsCaloric restriction, high protein, Caloric restriction, normal protein, Nutrition Education
NCT00473031 nacompletednot on this map

Nutritional Regulation of Bone - Aim 1

TypeinterventionalSponsorRutgers UniversityRan2007 to 2010Enrolled60ConditionsWeight Loss, Bone DensityArmsCaloric restriction, high protein, Caloric restriction, normal protein, Counseling
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 9 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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  8. The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Pooled it
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  10. Effect of protein supplementation on hip bone mineral density, cortical thickness, and bone strength in older adult participants during a caloric restriction and aerobic exercise weight loss intervention: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  17. Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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  18. Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
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  20. The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults.The Journal of clinical endocrinology and metabolism · 2015
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Deeptha SukumarDepartment of nutritional sciences rutgers university, New Brunswick, NJ 08901-8525, USA.
Hasina Ambia-Sobhan
Robert Zurfluh
Yvette Schlussel
Theodore J Stahl
Chris L Gordon
Sue A Shapses
Rutgers, The State University of New Jersey · USMcMaster University · CA

Funding

NUTRITIONAL REGULATION OF BONE TURNOVERR01AG012161 · NIA · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI SHAPSES, SUE AMY · 2000 to 2014
$3.4M
NIA NIH HHS R01 AG012161NIA NIH HHS R01-AG12161
6 · The paper itself

Abstract

Weight reduction induces bone loss by several factors, and the effect of higher protein (HP) intake during caloric restriction on bone mineral density (BMD) is not known. Previous study designs examining the longer-term effects of HP diets have not controlled for total calcium intake between groups and have not examined the relationship between bone and endocrine changes. In this randomized, controlled study, we examined how BMD (areal and volumetric), turnover markers, and hormones [insulin-like growth factor 1 (IGF-1), IGF-binding protein 3 (IGFBP-3), 25-hydroxyvitamin D, parathyroid hormone (PTH), and estradiol] respond to caloric restriction during a 1-year trial using two levels of protein intake. Forty-seven postmenopausal women (58.0 ± 4.4 years; body mass index of 32.1 ± 4.6 kg/m(2) ) completed the 1-year weight-loss trial and were on a higher (HP, 24%, n = 26) or normal protein (NP, 18%, n = 21) and fat intake (28%) with controlled calcium intake of 1.2 g/d. After 1 year, subjects lost 7.0% ± 4.5% of body weight, and protein intake was 86 and 60 g/d in the HP and NP groups, respectively. HP compared with NP diet attenuated loss of BMD at the ultradistal radius, lumbar spine, and total hip and trabecular volumetric BMD and bone mineral content of the tibia. This is consistent with the higher final values of IGF-1 and IGFBP-3 and lower bone-resorption marker (deoxypyridinoline) in the HP group than in the NP group (p < .05). These data show that a higher dietary protein during weight reduction increases serum IGF-1 and attenuates total and trabecular bone loss at certain sites in postmenopausal women.

Indexed as

Caloric RestrictionAgedBody CompositionBody WeightBone and BonesBone DensityBone RemodelingDietary ProteinsFemaleHormonesHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedParathyroid HormoneVitamin D25-hydroxyvitamin DDietary ProteinsHormonesInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IParathyroid HormoneVitamin D

Identifiers

PMID21611972
PMCPMC3312759
OpenAlexW2046906493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.