ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
- Prevalence and possible risk factors of low bone mineral density in untreated female patients with systemic lupus erythematosus.BioMed research international · 2015Trial
- Cardiovascular-specific PTH1R activation enhances exercise-induced cardiac remodeling in a mouse model of calcific atherosclerosis.Biochemical and biophysical research communications · 2026Article
- Specific serotonin receptor antagonist reduces murine calcific atherosclerosis.Atherosclerosis · 2026Article
- Correlation between cholesterol and ambulatory blood pressure in postmenopausal osteoporotic patients: aFrontiers in medicine · 2025Article
- Article
- The Effect of Hyperlipidemia on Peri-implant Health: A Clinical and Radiographical Prospective Study.BioMed research international · 2023Observational
- Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fedFrontiers in cell and developmental biology · 2023Article
- Impact of seborrheic dermatitis on osteoporosis risk: A population-based cohort study.The Journal of dermatology · 2022Article
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Association of dyslipidaemia with osteoporosis in postmenopausal women.The Journal of international medical research · 2021Article
- PTH/PTHrP Receptor Signaling Restricts Arterial Fibrosis in Diabetic LDLRCirculation research · 2020Article
- Dual Effects of Lipid Metabolism on Osteoblast Function.Frontiers in endocrinology · 2020Review
- Association Between Bone Mineral Density and Lipid Profile in Chinese Women.Clinical interventions in aging · 2020Article
- Review
- Energy-Dense Diets and Mineral Metabolism in the Context of Chronic Kidney Disease⁻Metabolic Bone Disease (CKD-MBD).Nutrients · 2018Review
- Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.American journal of physiology. Heart and circulatory physiology · 2018Article
- Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes.Frontiers in endocrinology · 2018Article
- Oxidized phospholipids are ligands for LRP6.Bone research · 2018Article
- High Fructose and High Fat Exert Different Effects on Changes in Trabecular Bone Micro-structure.The journal of nutrition, health & aging · 2018Article
- Association between Serum Cholesterol Level and Osteoporotic Fractures.Frontiers in endocrinology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In hyperlipidemia, oxidized lipids accumulate in vascular tissues and trigger atherosclerosis. Such lipids also deposit in bone tissues, where they may promote osteoporosis. We found previously that oxidized lipids attenuate osteogenesis and that parathyroid hormone (PTH) bone anabolism is blunted in hyperlipidemic mice, suggesting that osteoporotic patients with hyperlipidemia may develop resistance to PTH therapy. To determine if oxidized lipids account for this PTH resistance, we blocked lipid oxidation products in hyperlipidemic mice with an ApoA-I mimetic peptide, D-4F, and the bone anabolic response to PTH treatment was assessed. Skeletally immature Ldlr(-/-) mice were placed on a high-fat diet and treated with D-4F peptide and/or with intermittent PTH(1-34) injections. As expected, D-4F attenuated serum lipid oxidation products and tissue lipid deposition induced by the diet. Importantly, D-4F treatment attenuated the adverse effects of dietary hyperlipidemia on PTH anabolism by restoring micro-computed tomographic parameters of bone quality-cortical mineral content, area, and thickness. D-4F significantly reduced serum markers of bone resorption but not bone formation. PTH and D-4F, together but not separately, also promoted bone anabolism in an alternative model of hyperlipidemia, Apoe(-/-) mice. In normolipemic mice, D-4F cotreatment did not further enhance the anabolic effects of PTH, indicating that the mechanism is through its effects on lipids. These findings suggest that oxidized lipids mediate hyperlipidemia-induced PTH resistance in bone through modulation of bone resorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.