ReviewLangenbeck's archives of surgery2011
Gastric carcinogenesis.
Review in Langenbeck's archives of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Association between TLR4 (+896A/G and +1196C/T) polymorphisms and gastric cancer risk: an updated meta-analysis.PloS one · 2014Pooled it
- ANKRD1 expression and functional mechanism in stomach adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Rosmanol Triggers Apoptosis Against MNNG-induced Gastric Carcinogenesis in Rats through Attenuation of the P13K/AKT/HMBG1 Signaling Pathway.Combinatorial chemistry & high throughput screening · 2025Article
- Review
- Role of microRNA-494 in tumor progression.American journal of translational research · 2023Review
- Confusion and prospects for carcinogenesis of gastric adenoma and dysplasia: What is the correct answer currently?World journal of gastroenterology · 2022Review
- Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?Journal of gastroenterology and hepatology · 2022Article
- Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer.World journal of gastroenterology · 2021Review
- Epigenetic Mechanisms in Gastric Cancer: Potential New Therapeutic Opportunities.International journal of molecular sciences · 2020Review
- Toll-like receptor 2 and 4 polymorphisms associated with Helicobacter pylori susceptibility and gastric cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Article
- Deep learning analyzes Helicobacter pylori infection by upper gastrointestinal endoscopy images.Endoscopy international open · 2018Article
- Histopathological Changes in Laparoscopic Sleeve Gastrectomy Specimens: Prevalence, Risk Factors, and Value of Routine Histopathologic Examination.Obesity surgery · 2017Article
- Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua.BMC evolutionary biology · 2016Article
- Helicobacter pylori in gastric carcinogenesis.World journal of gastrointestinal oncology · 2015Review
- IsBariatric surgical practice and patient care · 2015Article
- Correlation analysis of riboflavin, RFT2 and Helicobater pylori in gastric carcinoma.International journal of clinical and experimental pathology · 2015Article
- Helicobacter pylori infection: new pathogenetic and clinical aspects.World journal of gastroenterology · 2014Review
- Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis.Cancer cell international · 2013Article
- Clinical significance of EBP50 overexpression assessed by quantum dot analysis in gastric cancer.Oncology letters · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn most patients, gastric cancer is diagnosed in advanced stage. Curative treatment options are limited and the mortality is high. The process of gastric carcinogenesis is triggered by Helicobacter pylori-driven gastritis and is further characterized by its complexity of interaction with other risk factors. Health care systems are challenged for the improvement of prevention, early diagnosis, and effective treatments.
methodsAn extensive literature research has been performed to elucidate the interplay between etiological factors involved in gastric carcinogenesis.
resultsH. pylori is the most important carcinogen for gastric adenocarcinoma. Evidence is provided by experiments including animal studies as well as clinical observational and interventional studies in humans. Eradication has the potential to prevent gastric cancer and offers the greatest benefit if performed before premalignant changes of the gastric mucosa have occurred. Bacterial virulence factors are essential players in modulating the immune response involved in the initiation of the carcinogenesis in the stomach. Host genetic factors contribute to the regulation of the inflammatory response and in the aggravation of mucosal damage. The harmful role of environmental factors is restricted to salt intake and smoking of tobacco. The ingestion of fruit and vegetables has some protective effect.
conclusionInfection with H. pylori is the major risk factor for gastric cancer development, and thus, eradication of the Helicobacter offers a promising best option for prevention of the disease. Bacterial virulence, host genetic factors, and environmental influences are interacting in the multifactorial process of gastric carcinogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.