ArticleJournal of materials science. Materials in medicine2011
Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- A Histologic, Histomorphometric, and Immunohistochemical Evaluation of Anorganic Bovine Bone and Injectable Biphasic Calcium Phosphate in Humans: A Randomized Clinical Trial.International journal of molecular sciences · 2023Trial
- A 25-Year Review of the Use of Silanized Hydroxypropylmethylcellulose Hydrogels in Tissue Engineering and Regenerative Medicine.Macromolecular bioscience · 2026Review
- BMP-2-Loaded Self-Crosslinking CaP/Hydrogel Composite Enables Complete Regeneration of Critical-Sized Segmental Bone Defects.Bioengineering (Basel, Switzerland) · 2026Article
- New Insights in Hydrogels for Periodontal Regeneration.Journal of functional biomaterials · 2023Review
- Injectable Hydrogel Membrane for Guided Bone Regeneration.Bioengineering (Basel, Switzerland) · 2023Article
- Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs.Biomaterials research · 2022Article
- Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies.Materials (Basel, Switzerland) · 2021Review
- Recent advances in periodontal regeneration: A biomaterial perspective.Bioactive materials · 2020Article
- The association of hydrogel and biphasic calcium phosphate in the treatment of dehiscence-type peri-implant defects: an experimental study in dogs.Journal of materials science. Materials in medicine · 2013Article
- Calcium orthophosphates in dentistry.Journal of materials science. Materials in medicine · 2013Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An injectable composite silanized hydroxypropyl methyl cellulose/biphasic calcium phosphate (Si-HPMC/BCP) has been investigated in humans with promising results. The aim of this study was to evaluate his efficacy for treating periodontal defects (canine fenestration and premolar furcation) in dog models. At 3 months, we observed that bone formation around BCP particles in furcation model is more discernible but not statistically significant in defects filled with Si-HPMC/BCP compared to healing in control. We suggest that BCP particles sustain the bone healing process by osteoconduction, while the Si-HPMC hydrogel enhances intergranular cohesion and acts as an exclusion barrier. Furthermore, bone ingrowth is not so distinctive in superficial defects where the biomaterial appears unstable. These results with Si-HPMC/BCP are encouraging. In addition, this biomaterial is easy to use and simplifies the process of filling periodontal lesions. However, more researches are needed to improve the viscosity and hardness to adjust the material to the specificities of periodontal defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.