ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2011
Lipid-soluble ginseng extract induces apoptosis and G0/G1 cell cycle arrest in NCI-H460 human lung cancer cells.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Phytochemistry, pharmacological effects and mechanism of action of volatile oil fromFrontiers in pharmacology · 2024Review
- Red ginseng (Journal of ginseng research · 2022Review
- Effects of Acanthus ebracteatus Vahl. extract and verbascoside on human dermal papilla and murine macrophage.Scientific reports · 2022Article
- New Insights into the Mechanisms of Polyphenol from Plum Fruit Inducing Apoptosis in Human Lung Cancer A549 Cells Via PI3K/AKT/FOXO1 Pathway.Plant foods for human nutrition (Dordrecht, Netherlands) · 2021Article
- Inhibition of Hepatocellular Carcinoma Growth by Ethyl Acetate Extracts of Apulian Brassica oleracea L. and Crithmum maritimum L.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Article
- Comparative Study of Onion (Allium cepa) and Leek (Allium ampeloprasum): Identification of Organosulphur Compounds by UPLC-QTOF/MS and Anticancer Effect on MCF-7 Cells.Plant foods for human nutrition (Dordrecht, Netherlands) · 2019Article
- Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells.Journal of ginseng research · 2018Article
- Protective Effects of Red Ginseng Oil against AβInternational journal of molecular sciences · 2017Article
- An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells.Molecules (Basel, Switzerland) · 2016Article
- Lipid-soluble ginseng extract inhibits invasion and metastasis of B16F10 melanoma cells.Journal of medicinal food · 2015Article
- A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis.Journal of biomedicine & biotechnology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to elucidate the anticancer mechanism of a lipid-soluble ginseng extract (LSGE) by analyzing induction of apoptosis and arrest of cell cycle progression using the NCI-H460 human lung cancer cell line. Proliferation of NCI-H460 cells was potently inhibited by LSGE in a dose-dependent manner. The cell cycle arrest at the G0/G1 phase in NCI-H460 cells was induced by LSGE. The percentage of G0/G1 phase cells significantly increased, while that of S phase cells decreased after treatment with LSGE. The expression levels of cyclin-dependent kinase2 (CDK2), CDK4, CDK6, cyclin D3 and cyclin E related to G0/G1 cells progression were also altered by LSGE. In addition, LSGE-induced cell death occurred through apoptosis, which was accompanied by increasing the activity of caspases including caspase-8, caspase-9 and caspase-3. Consistent with enhancement of caspase activity, LSGE increased protein levels of cleaved caspase-3, caspase-8, caspase-9, and poly-ADP-ribose polymerase (PARP). These apoptotic effects of LSGE were inhibited by the pan-caspase inhibitor Z-VAD-fmk. These findings indicate that LSGE inhibits NCI-H460 human lung cancer cell growth by cell cycle arrest at the G0/G1 phase and induction of caspase-mediated apoptosis.
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