SynthesisMolecular biology reports2012
Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses.Journal of immunology research · 2024Pooled it
- IL-18 polymorphisms (-137C/G and -607A/C) are not associated with tuberculosis.Innate immunity · 2019Pooled it
- Association of IL-18 promoter gene polymorphisms with rheumatoid arthritis: a meta-analysis.Molecular biology reports · 2014Pooled it
- The relationship between interleukin-18 polymorphisms and allergic disease: a meta-analysis.BioMed research international · 2014Pooled it
- Significant association between GSTT1 null genotype and risk of asthma during childhood in Caucasians.Molecular biology reports · 2013Pooled it
- Association between TNF-α, Interleukin-18 Polymorphisms and Risk of Hepatocellular Carcinoma in Egyptian patients.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level.Central-European journal of immunology · 2019Article
- Article
- Interleukin-18 -607C/A gene polymorphism in Egyptian asthmatic children.Molecular diagnosis & therapy · 2014Article
- Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis.Molecular biology reports · 2014Article
- Article
- Licensing Adaptive Immunity by NOD-Like Receptors.Frontiers in immunology · 2013Review
- Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma.Immunologic research · 2012Review
- Association of interleukin-18 gene polymorphism with body mass index in women.Reproductive biology and endocrinology : RB&E · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some studies have shown that IL-18 was associated with aetiology and progression of asthma. However, the association between single-nucleotide polymorphisms -607C/A (rs1946518) and -137G/C (rs187238) located in the IL-18 gene promoter and asthma risk was still controversial and ambiguous. To derive a more precise effect on the association between these polymorphisms and asthma risk, we performed a meta-analysis based on the currently available evidence of the literature. A total of 5 studies with 1411 cases and 1525 controls for -607C/A polymorphism and 5 studies with 1883 cases and 6645 controls for -137G/C polymorphism were identified to perform a meta-analysis, up to October 2010. Summary ORs and corresponding 95% CIs for IL-18 polymorphisms and asthma were estimated using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. We found that individuals carrying AC/CC genotype of -607C/A polymorphism were associated with an increased asthma risk in recessive model (OR = 1.278; 95% CI, 1.073-1.522). However, no significant association was observed between -137G/C polymorphism and asthma risk under different contrast models. There was no evidence of publication bias. The present meta-analysis suggested that IL-18 -607C/A polymorphism in promoter region was associated with asthma risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.