ArticlePloS one2011
Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.Eye (London, England) · 2022Pooled it
- Autoimmune retinopathy with associated anti-retinal antibodies as a potential immune-related adverse event associated with immunotherapy in patients with advanced cutaneous melanoma: case series and systematic review.BMJ open ophthalmology · 2022Pooled it
- Electronegative ERG in association with probable TRPM1-related cancer associated retinopathy: a case report.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Diagnosis and treatment of autoimmune retinopathy: review of current approaches.International ophthalmology · 2025Review
- Genetic Loss of RORα Impairs Visual Function With Rod Bipolar Cell Degeneration In Mice.Investigative ophthalmology & visual science · 2025Article
- Article
- Emerging Ocular Side Effects of Immune Checkpoint Inhibitors: A Comprehensive Review.Biomedicines · 2024Review
- The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism.Investigative ophthalmology & visual science · 2024Article
- B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma.Nature communications · 2023Article
- Melanoma-associated retinopathy with anti-TRPM1 autoantibodies showing concomitant Off-bipolar cell dysfunction.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Negative electroretinograms: genetic and acquired causes, diagnostic approaches and physiological insights.Eye (London, England) · 2021Review
- Melanoma-associated retinopathy during pembrolizumab treatment probably controlled by intravitreal injections of dexamethasone.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Clinical Findings of Melanoma-Associated Retinopathy with anti-TRPM1 Antibody.Case reports in ophthalmological medicine · 2021Article
- Prevalence of electronegative electroretinograms in a healthy adult cohort.BMJ open ophthalmology · 2021Article
- A case of melanoma-associated retinopathy with autoantibodies against TRPM1.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.Documenta ophthalmologica. Advances in ophthalmology · 2020Review
- Identification and characterization of novel TRPM1 autoantibodies from serum of patients with melanoma-associated retinopathy.PloS one · 2020Article
- Two cases of unilateral cone-rod dysfunction with negative electroretinograms.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- A case of cancer-associated retinopathy with chorioretinitis and optic neuritis associated with occult small cell lung cancer.BMC ophthalmology · 2019Article
- TRPM1 Autoantibodies in Melanoma Patients Without Self-Reported Visual Symptoms.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundParaneoplastic retinopathy (PR), including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR), is a progressive retinal disease caused by antibodies generated against neoplasms not associated with the eye. While several autoantibodies against retinal antigens have been identified, there has been no known autoantibody reacting specifically against bipolar cell antigens in the sera of patients with PR. We previously reported that the transient receptor potential cation channel, subfamily M, member 1 (TRPM1) is specifically expressed in retinal ON bipolar cells and functions as a component of ON bipolar cell transduction channels. In addition, this and other groups have reported that human TRPM1 mutations are associated with the complete form of congenital stationary night blindness. The purpose of the current study is to investigate whether there are autoantibodies against TRPM1 in the sera of PR patients exhibiting ON bipolar cell dysfunction. METHODOLOGY/PRINCIPAL
findingsWe performed Western blot analysis to identify an autoantibody against TRPM1 in the serum of a patient with lung CAR. The electroretinograms of this patient showed a severely reduced ON response with normal OFF response, indicating that the defect is in the signal transmission between photoreceptors and ON bipolar cells. We also investigated the sera of 26 patients with MAR for autoantibodies against TRPM1 because MAR patients are known to exhibit retinal ON bipolar cell dysfunction. Two of the patients were found to have autoantibodies against TRPM1 in their sera. CONCLUSION/SIGNIFICANCE: Our study reveals TRPM1 to be one of the autoantigens targeted by autoantibodies in at least some patients with CAR or MAR associated with retinal ON bipolar cell dysfunction.
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Registered trials
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