ArticlePloS one2011
Genomic characterization of Haemophilus parasuis SH0165, a highly virulent strain of serovar 5 prevalent in China.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Research progress into the principles and methods underlying capsular typing of Glaesserella parasuis.Veterinary research · 2024Pooled it
- Review
- Global whole-genome, phylodynamic, and machine-learning analysis ofApplied and environmental microbiology · 2026Article
- Article
- Isolation, Antimicrobial Susceptibility, and Genotypes of ThreeMicroorganisms · 2025Article
- Transcriptional profile ofFrontiers in veterinary science · 2025Article
- Research progress onFrontiers in veterinary science · 2025Review
- Transcriptome analysis reveals a new virulence-associated trimeric autotransporter responsible for Glaesserella parasuis autoagglutination.Veterinary research · 2024Article
- Pan-genome wide association study ofFrontiers in microbiology · 2023Article
- Generation of markerless and multiple-gene knockout in Glaesserella parasuis based on natural transformation and Flp recombinase.Applied microbiology and biotechnology · 2022Article
- Expression Analysis of Outer Membrane Protein HPS_06257 in Different Strains ofVeterinary sciences · 2022Article
- Application of mouse model for evaluation of recombinant LpxC and GmhA as novel antigenic vaccine candidates of Glaesserella parasuis serotype 13.The Journal of veterinary medical science · 2021Article
- Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant.Infection and immunity · 2020Article
- Article
- Pasteurella multocida: Genotypes and Genomics.Microbiology and molecular biology reviews : MMBR · 2019Review
- Porcine Alveolar Macrophages' Nitric Oxide Synthase-Mediated Generation of Nitric Oxide Exerts Important Defensive Effects againstPathogens (Basel, Switzerland) · 2019Article
- Complete Genome Sequence Analysis and Characterization of Selected Iron Regulation Genes ofGenes · 2019Article
- Association betweenPeerJ · 2019Article
- Transcriptomic differences noted in Glaesserella parasuis between growth in broth and on agar.PloS one · 2019Article
- Haemophilus parasuis α-2,3-sialyltransferase-mediated lipooligosaccharide sialylation contributes to bacterial pathogenicity.Virulence · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus parasuis can be either a commensal bacterium of the porcine respiratory tract or an opportunistic pathogen causing Glässer's disease, a severe systemic disease that has led to significant economical losses in the pig industry worldwide. We determined the complete genomic sequence of H. parasuis SH0165, a highly virulent strain of serovar 5, which was isolated from a hog pen in North China. The single circular chromosome was 2,269,156 base pairs in length and contained 2,031 protein-coding genes. Together with the full spectrum of genes detected by the analysis of metabolic pathways, we confirmed that H. parasuis generates ATP via both fermentation and respiration, and possesses an intact TCA cycle for anabolism. In addition to possessing the complete pathway essential for the biosynthesis of heme, this pathogen was also found to be well-equipped with different iron acquisition systems, such as the TonB system and ABC-type transport complexes, to overcome iron limitation during infection and persistence. We identified a number of genes encoding potential virulence factors, such as type IV fimbriae and surface polysaccharides. Analysis of the genome confirmed that H. parasuis is naturally competent, as genes related to DNA uptake are present. A nine-mer DNA uptake signal sequence (ACAAGCGGT), identical to that found in Actinobacillus pleuropneumoniae and Mannheimia haemolytica, followed by similar downstream motifs, was identified in the SH0165 genome. Genomic and phylogenetic comparisons with other Pasteurellaceae species further indicated that H. parasuis was closely related to another swine pathogenic bacteria A. pleuropneumoniae. The comprehensive genetic analysis presented here provides a foundation for future research on the metabolism, natural competence and virulence of H. parasuis.
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