Evidence map›Paper›PMID 21610741›Full record

ReviewNature reviews. Immunology2011

Diversity and dialogue in immunity to helminths.

Judith E Allen, Rick M Maizels

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 458 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
458citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

458 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
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  11. Ameliorative effects ofThe journal of allergy and clinical immunology. Global · 2026
    Article
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  13. Review
  14. Article
  15. Seroprevalence and Risk Factors Associated with Anti-International journal of environmental research and public health · 2026
    Article
  16. Article
  17. Review
  18. Immune development in early life.Nature immunology · 2026
    Review
  19. Article
  20. Article

398 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Judith E AllenInstitute for Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, UK.
Rick M Maizels

Funding

Medical Research Council G0600818Wellcome Trust
6 · The paper itself

Abstract

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.

Indexed as

AnimalsAntigenic VariationCytokinesGenetic VariationHelminthiasisHelminthsHost-Parasite InteractionsHumansImmunityModels, ImmunologicalTh2 CellsCytokines

Identifiers

PMID21610741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.