ArticleBritish journal of cancer2011
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Development of a Nucleoside Photosensitizer Efficiently Activated by One- or Two-Photon Absorption in the Optical Therapeutic Window.Journal of the American Chemical Society · 2026Article
- Quantum-Chemistry Study of the Photophysical Properties of 4-Thiouracil and Comparisons with 2-Thiouracil.The journal of physical chemistry. A · 2024Article
- Double Thionated Pyrimidine Nucleobases: Molecular Tools with Tunable Photoproperties.Journal of the American Chemical Society · 2023Article
- Ultrafast Excited-State Decay Mechanisms of 6-Thioguanine Followed by Sub-20 fs UV Transient Absorption Spectroscopy.Molecules (Basel, Switzerland) · 2022Article
- Thionated organic compounds as emerging heavy-atom-free photodynamic therapy agents.Chemical science · 2020Review
- Excited State Lifetimes of Sulfur-Substituted DNA and RNA Monomers Probed Using the Femtosecond Fluorescence Up-Conversion Technique.Molecules (Basel, Switzerland) · 2020Article
- Radiation Induced One-Electron Oxidation of 2-Thiouracil in Aqueous Solutions.Molecules (Basel, Switzerland) · 2019Article
- Simulated and Experimental Time-Resolved Photoelectron Spectra of the Intersystem Crossing Dynamics in 2-Thiouracil.Molecules (Basel, Switzerland) · 2018Article
- Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA.Free radical biology & medicine · 2017Review
- Solvatochromic Effects on the Absorption Spectrum of 2-Thiocytosine.The journal of physical chemistry. B · 2017Article
- The origin of efficient triplet state population in sulfur-substituted nucleobases.Nature communications · 2016Article
- Intersystem Crossing Pathways in the Noncanonical Nucleobase 2-Thiouracil: A Time-Dependent Picture.The journal of physical chemistry letters · 2016Article
- Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides byBeilstein journal of organic chemistry · 2016Article
- UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions.Journal of photochemistry and photobiology. B, Biology · 2015Article
- Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells.Nucleic acids research · 2011Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThiothymidine (S(4)TdR) can be incorporated into DNA and sensitise cells to DNA damage and cell death following exposure to UVA light. Studies were performed to determine if the combination of S(4)TdR and UVA could be an effective treatment for bladder cancer.
methodsUptake and incorporation of S(4)TdR was determined in rat and human bladder tumour cell lines. Measures of DNA crosslinking and apoptosis were also performed. In vivo activity of the combination of S(4)TdR and UVA was investigated in an orthotopic model of bladder cancer in rats.
resultsThiothymidine (200 μM) replaced up to 0.63% of thymidine in rat and tumour bladder cancer cells. The combination of S(4)TdR (10-200 μM) and UVA (1-5 kJ m(-2)) caused apoptosis and cell death at doses that were not toxic alone. Addition of raltitrexed (Astra Zeneca, Alderley Edge, Cheshire, UK) increased the incorporation of S(4)TdR into DNA (up to 20-fold at IC(5)) and further sensitised cells to UVA. Cytotoxic effect was associated with crosslinking of DNA, at least partially to protein. Intravenous administration of S(4)TdR, in combination with UVA delivered directly to the bladder, resulted in an antitumour effect in three of five animals treated.
conclusionThese data indicate that the combination of S(4)TdR and UVA has potential as a treatment for bladder cancer, and give some insight into the mechanism of action. Further work is necessary to optimise the delivery of the two components.
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