ArticleJournal of visualized experiments : JoVE2011
An in vivo rodent model of contraction-induced injury and non-invasive monitoring of recovery.
Article in Journal of visualized experiments : JoVE, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Neuromuscular Regeneration of Volumetric Muscle Loss Injury in Response to Agrin-Functionalized Tissue Engineered Muscle Grafts and Rehabilitative Exercise.Advanced healthcare materials · 2025Article
- Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice.Journal of cachexia, sarcopenia and muscle · 2023Article
- E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage.Journal of visualized experiments : JoVE · 2022Article
- Muscle phenotype of a rat model of Duchenne muscular dystrophy.Muscle & nerve · 2020Article
- Differential YAP nuclear signaling in healthy and dystrophic skeletal muscle.American journal of physiology. Cell physiology · 2019Article
- Diltiazem improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage.Physiological reports · 2018Article
- Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.BMC musculoskeletal disorders · 2017Article
- A method to test contractility of the supraspinatus muscle in mouse, rat, and rabbit.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Myofiber damage precedes macrophage infiltration after in vivo injury in dysferlin-deficient A/J mouse skeletal muscle.The American journal of pathology · 2015Article
- A stepwise procedure to test contractility and susceptibility to injury for the rodent quadriceps muscle.Journal of biological methods · 2014Article
- Dysferlin at transverse tubules regulates Ca(2+) homeostasis in skeletal muscle.Frontiers in physiology · 2014Review
- Dysferlin stabilizes stress-induced Ca2+ signaling in the transverse tubule membrane.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles.The Journal of physiology · 2013Article
- Early metabolic changes measured by 1H MRS in healthy and dystrophic muscle after injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Article
- Distinct effects of contraction-induced injury in vivo on four different murine models of dysferlinopathy.Journal of biomedicine & biotechnology · 2012Article
- Physiological and histological changes in skeletal muscle following in vivo gene transfer by electroporation.American journal of physiology. Cell physiology · 2011Article
- Diffusion tensor MRI to assess damage in healthy and dystrophic skeletal muscle after lengthening contractions.Journal of biomedicine & biotechnology · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Muscle strains are one of the most common complaints treated by physicians. A muscle injury is typically diagnosed from the patient history and physical exam alone, however the clinical presentation can vary greatly depending on the extent of injury, the patient's pain tolerance, etc. In patients with muscle injury or muscle disease, assessment of muscle damage is typically limited to clinical signs, such as tenderness, strength, range of motion, and more recently, imaging studies. Biological markers, such as serum creatine kinase levels, are typically elevated with muscle injury, but their levels do not always correlate with the loss of force production. This is even true of histological findings from animals, which provide a "direct measure" of damage, but do not account for all the loss of function. Some have argued that the most comprehensive measure of the overall health of the muscle in contractile force. Because muscle injury is a random event that occurs under a variety of biomechanical conditions, it is difficult to study. Here, we describe an in vivo animal model to measure torque and to produce a reliable muscle injury. We also describe our model for measurement of force from an isolated muscle in situ. Furthermore, we describe our small animal MRI procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.