ReviewEpigenetics2011
Environmental epigenetics in metal exposure.
Review in Epigenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 316 citations in OpenAlex.
- Chromium as a Risk Factor for Breast Cancer: A Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2022Pooled it
- Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.International journal of environmental research and public health · 2026Review
- A comparative genotoxicity study of agrochemicals: nuclear abnormalities, comet assay, and gene expression alterations.In vitro cellular & developmental biology. Animal · 2026Article
- Impact of Arsenite on Transient and Persistent Histone H3 Modifications and Transcriptional Response.Chemical research in toxicology · 2026Article
- Timing of dietary effects on the epigenome and their potential protective effects against toxins.Epigenetics · 2025Review
- Heavy Metal-Contaminated Soils and Gastric Cancer Risk: Molecular Insights and the Relevance of a One Health Perspective.International journal of molecular sciences · 2025Review
- Epigenetic changes and their potential reversibility in mental health disorders.Essays in biochemistry · 2025Review
- Arsenic promotes ROS-mediated malignant transformation of bronchial epithelial cells by specifically downregulating TXNL1 expression.Communications biology · 2025Article
- Epigenetics: A link between toxicants and diseases.iScience · 2025Review
- Observational methods for human studies of transgenerational effects.Epigenetics · 2024Article
- DNA Methylation as a Molecular Mechanism of Carcinogenesis in World Trade Center Dust Exposure: Insights from a Structured Literature Review.Biomolecules · 2024Review
- Implications of Lead (Pb)-Induced Transcriptomic and Phenotypic Alterations in the Aged Zebrafish (Toxics · 2024Article
- The Role of Trace Metals in the Development and Progression of Prostate Cancer.International journal of molecular sciences · 2024Review
- Epigenetics and environmental health.Frontiers of medicine · 2024Review
- Cadmium transport by mammalian ATP-binding cassette transporters.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Genome-wide DNA methylation profiles and breast cancer among World Trade Center survivors.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Bioaccumulation Capacity of Onion (Molecules (Basel, Switzerland) · 2023Article
- World Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence.Epigenomes · 2023Review
- A Comprehensive Review on the Roles of Metals Mediating Insect-Microbial Pathogen Interactions.Metabolites · 2023Review
- Nutriepigenomics in Environmental-Associated Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although it is widely accepted that chronic exposure to arsenite, nickel, chromium and cadmium increases cancer incidence in individuals, the molecular mechanisms underlying their ability to transform cells remain largely unknown. Carcinogenic metals are typically weak mutagens, suggesting that genetic-based mechanisms may not be primarily responsible for metal-induced carcinogenesis. Growing evidence shows that environmental metal exposure involves changes in epigenetic marks, which may lead to a possible link between heritable changes in gene expression and disease susceptibility and development. Here, we review recent advances in the understanding of metal exposure affecting epigenetic marks and discuss establishment of heritable gene expression in metal-induced carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.