Evidence map›Paper›PMID 21610212›Full record

ArticleRNA (New York, N.Y.)2011

Sharing and archiving nucleic acid structure mapping data.

Philippe Rocca-Serra, Stanislav Bellaousov, Amanda Birmingham, Chunxia Chen, Pablo Cordero, Rhiju Das, Lauren Davis-Neulander, Caia D S Duncan, Matthew Halvorsen, Rob Knight and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. High-throughput determination of RNA structures.Nature reviews. Genetics · 2018
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The mutate-and-map protocol for inferring base pairs in structured RNA.Methods in molecular biology (Clifton, N.J.) · 2014
    Article
  13. Accurate SHAPE-directed RNA secondary structure modeling, including pseudoknots.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  14. Article
  15. Article
  16. Article
  17. The mechanisms of RNA SHAPE chemistry.Journal of the American Chemical Society · 2012
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Philippe Rocca-SerraOxford e-Research Center, University of Oxford, OX1 3QG, Oxford, United Kingdom.
Stanislav Bellaousov
Amanda Birmingham
Chunxia Chen
Pablo Cordero
Rhiju Das
Lauren Davis-Neulander
Caia D S Duncan
Matthew Halvorsen
Rob Knight
Neocles B Leontis
David H Mathews
Justin Ritz
Jesse Stombaugh
Kevin M Weeks
Craig L Zirbel
Alain Laederach
University of North Carolina at Chapel Hill · USBowling Green State University · USStanford University · USUniversity of Rochester · USHoward Hughes Medical Institute · USThermo Fisher Scientific (United States) · USUniversity of Colorado Boulder · USUniversity of Oxford · GB

Funding

Structure of the HIV-1 GenomeR01AI068462 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2006 to 2020
$7.4M
RNA 3D Motif Search, Atlas, and Prediction from SequenceR01GM085328 · NIGMS · BOWLING GREEN STATE UNIVERSITY · PI ZIRBEL, CRAIG L · 2010 to 2023
$4.0M
Multi-Scale Dynamic Modeling of RNA Folding and AssemblyR00GM079953 · NIGMS · WADSWORTH CENTER · PI LAEDERACH, ALAIN T · 2008 to 2010
$969k
Identifying Disease-Associated Mutations That Alter RNA StructureR21MH087336 · NIMH · WADSWORTH CENTER · PI CURCIO, M JOAN · 2009 to 2010
$471k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI068462NIAID NIH HHS R01AI068462NIGMS NIH HHS R00 GM079953NIGMS NIH HHS R00GM079953NIGMS NIH HHS R01GM07648NIGMS NIH HHS R01 GM085328NIMH NIH HHS R21 MH087336NIMH NIH HHS R21MH087336
6 · The paper itself

Abstract

Nucleic acids are particularly amenable to structural characterization using chemical and enzymatic probes. Each individual structure mapping experiment reveals specific information about the structure and/or dynamics of the nucleic acid. Currently, there is no simple approach for making these data publically available in a standardized format. We therefore developed a standard for reporting the results of single nucleotide resolution nucleic acid structure mapping experiments, or SNRNASMs. We propose a schema for sharing nucleic acid chemical probing data that uses generic public servers for storing, retrieving, and searching the data. We have also developed a consistent nomenclature (ontology) within the Ontology of Biomedical Investigations (OBI), which provides unique identifiers (termed persistent URLs, or PURLs) for classifying the data. Links to standardized data sets shared using our proposed format along with a tutorial and links to templates can be found at http://snrnasm.bio.unc.edu.

Indexed as

Databases, Nucleic AcidInformation DisseminationNucleic Acid ConformationAlgorithmsArchivesBase SequenceChromosome MappingHumansMolecular Sequence DataNucleic AcidsResearch DesignRNAValidation Studies as TopicNucleic AcidsRNA

Identifiers

PMID21610212
PMCPMC3138558
OpenAlexW2146247729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.