ArticleMolecular & cellular proteomics : MCP2011
Comparative protein expression in different strains of the bloom-forming cyanobacterium Microcystis aeruginosa.
Article in Molecular & cellular proteomics : MCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Nitrogen Substrate Impacts Microcystis aeruginosa Exometabolome Composition.Environmental microbiology reports · 2025Article
- Microcystin aids in cold temperature acclimation: Differences between a toxic Microcystis wildtype and non-toxic mutant.Harmful algae · 2023Article
- Cool temperature acclimation in toxigenicbioRxiv : the preprint server for biology · 2023Article
- Heterotrophic Bacteria Dominate Catalase Expression duringApplied and environmental microbiology · 2022Article
- The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium.Marine drugs · 2019Article
- Determination of the Role ofToxins · 2018Article
- Article
- Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells.Scientific reports · 2017Article
- Influence of temperature, mixing, and addition of microcystin-LR on microcystin gene expression in Microcystis aeruginosa.MicrobiologyOpen · 2017Article
- Moving towards adaptive management of cyanotoxin-impaired water bodies.Microbial biotechnology · 2016Review
- Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake.The ISME journal · 2016Article
- A Metaproteomic Analysis of the Response of a Freshwater Microbial Community under Nutrient Enrichment.Frontiers in microbiology · 2016Article
- Microcystin Biosynthesis andBioMed research international · 2016Article
- Transcriptomics-aided dissection of the intracellular and extracellular roles of microcystin in Microcystis aeruginosa PCC 7806.Applied and environmental microbiology · 2015Article
- Long-term monitoring reveals carbon-nitrogen metabolism key to microcystin production in eutrophic lakes.Frontiers in microbiology · 2015Article
- Microcystin production and regulation under nutrient stress conditions in toxic microcystis strains.Applied and environmental microbiology · 2014Article
- Review
- Comparative genomics of Cylindrospermopsis raciborskii strains with differential toxicities.BMC genomics · 2014Article
- Interpreting the possible ecological role(s) of cyanotoxins: compounds for competitive advantage and/or physiological aide?Marine drugs · 2013Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxin production in algal blooms presents a significant problem for the water industry. Of particular concern is microcystin, a potent hepatotoxin produced by the unicellular freshwater species Microcystis aeruginosa. In this study, the proteomes of six toxic and nontoxic strains of M. aeruginosa were analyzed to gain further knowledge in elucidating the role of microcystin production in this microorganism. This represents the first comparative proteomic study in a cyanobacterial species. A large diversity in the protein expression profiles of each strain was observed, with a significant proportion of the identified proteins appearing to be strain-specific. In total, 475 proteins were identified reproducibly and of these, 82 comprised the core proteome of M. aeruginosa. The expression of several hypothetical and unknown proteins, including four possible operons was confirmed. Surprisingly, no proteins were found to be produced only by toxic or nontoxic strains. Quantitative proteome analysis using the label-free normalized spectrum abundance factor approach revealed nine proteins that were differentially expressed between toxic and nontoxic strains. These proteins participate in carbon-nitrogen metabolism and redox balance maintenance and point to an involvement of the global nitrogen regulator NtcA in toxicity. In addition, the switching of a previously inactive toxin-producing strain to microcystin synthesis is reported.
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