Trial reportPhysiological genomics2011
Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise.
Trial report in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- Article
- The Effect of a Nutritional Intervention with the Use of Biofortified Beef Meat on Selected Biochemical Parameters in Blood from Older Adults.Nutrients · 2024Article
- Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study.Journal of atherosclerosis and thrombosis · 2024Article
- Article
- Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis.Antioxidants (Basel, Switzerland) · 2022Article
- Translational Potential of High-Resistance Inspiratory Muscle Strength Training.Exercise and sport sciences reviews · 2022Article
- Time-efficient, high-resistance inspiratory muscle strength training for cardiovascular aging.Experimental gerontology · 2021Review
- Vascular Ageing and Aerobic Exercise.International journal of environmental research and public health · 2021Review
- Healthy Aging Interventions Reduce Repetitive Element Transcripts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Physical activity is associated with lower arterial stiffness in normal-weight postmenopausal women.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Cardiometabolic risk factors are associated with immune cell mitochondrial respiration in humans.American journal of physiology. Heart and circulatory physiology · 2020Article
- Exercise-associated prevention of adult cardiovascular disease in children and adolescents: monocytes, molecular mechanisms, and a call for discovery.Pediatric research · 2020Review
- Aerobic exercise training and vascular function with ageing in healthy men and women.The Journal of physiology · 2019Review
- Article
- Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance.Iranian journal of basic medical sciences · 2019Article
- Monocyte Subsets in Atherosclerosis and Modification with Exercise in Humans.Antioxidants (Basel, Switzerland) · 2018Review
- Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise.Genes & nutrition · 2017Article
- Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women.Korean journal of family medicine · 2016Article
- Feasibility of assessing health state by detecting redox state of human body based on Chinese medicine constitution.Chinese journal of integrative medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypothesis that peripheral blood mononuclear cells (PBMC) of older adults demonstrate a proinflammatory/-oxidative gene expression profile that can be improved by regular aerobic exercise. PBMC were isolated from young (n = 25, 18-33 yr) and middle-aged/older (n = 40, 50-76 yr) healthy adults. The older adults had greater mRNA expression (real-time RT-PCR) of the proinflammatory/-oxidant transcription factor nuclear factor-κB (1.58-fold, P < 0.05) and receptor for advanced glycation end products (1.12-fold, P < 0.05), the proinflammatory cytokines tumor necrosis factor-α (1.90-fold, P < 0.05) and monocyte chemoattractant protein-1 (1.47-fold, P < 0.05), and the oxidant-producing enzymes nicotinamide adenine dinucleotide phosphate-oxidase (0.91-fold, P < 0.05) and inducible nitric oxide synthase (2.60-fold, P < 0.05). In 11 subjects (58-70 yr), maximal oxygen consumption (+11%) and exercise time (+19%) were increased (both P < 0.001), and expression of the above proinflammatory/-oxidative genes was or tended to be decreased in PBMC after vs. before 2 mo of aerobic exercise (brisk walking ∼6 days/wk, 50 min/day, 70% of maximal heart rate). Expression of interleukin-6 was not different with age or exercise intervention. Age group- and exercise intervention-related differences in gene expression were independent of other factors. PBMC of healthy older adults demonstrate increased expression of several genes associated with inflammation and oxidative stress, which is largely ameliorated by habitual aerobic exercise. This proinflammatory/-oxidative gene signature may represent a therapeutic target for lifestyle and pharmacological prevention and treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.