Evidence map›Paper›PMID 21609780›Full record

ReviewMicrobes and infection2011

Yersiniabactin iron uptake: mechanisms and role in Yersinia pestis pathogenesis.

Robert D Perry, Jacqueline D Fetherston

Abstract readReview
In one paragraph

Review in Microbes and infection, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 175 citations in OpenAlex.

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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert D PerryDepartment of Microbiology, Immunology, and Molecular Genetics, MS415 Medical Center, University of Kentucky, Lexington, KY 40536-0298, USA. rperry@uky.edu
Jacqueline D Fetherston
University of Kentucky · US

Funding

Yersiniabactin and plague pathogenesisR01AI033481 · NIAID · UNIVERSITY OF KENTUCKY · PI PERRY, ROBERT DONALD · 1993 to 2013
$3.6M
Yersiniabactin and plague pathogenesisR56AI033481 · NIAID · UNIVERSITY OF KENTUCKY · PI PERRY, ROBERT DONALD · 2008 to 2008
$366k
NIAID NIH HHS AI-33481NIAID NIH HHS R01 AI033481NIAID NIH HHS R56 AI033481
6 · The paper itself

Abstract

Yersiniabactin (Ybt) is a siderophore-dependent iron uptake system encoded on a pathogenicity island that is widespread among pathogenic bacteria including the Yersiniae. While biosynthesis of the siderophore has been elucidated, the secretion mechanism and a few components of the uptake/utilization pathway are unidentified. ybt genes are transcriptionally repressed by Fur but activated by YbtA, likely in combination with the siderophore itself. The Ybt system is essential for the ability of Yersinia pestis to cause bubonic plague and important in pneumonic plague as well. However, the ability to cause fatal septicemic plague is independent of Ybt.

Indexed as

Gene Expression Regulation, BacterialHumansIronPhenolsPlagueThiazolesVirulence FactorsYersinia pestisIronPhenolsThiazolesVirulence Factorsyersiniabactin

Identifiers

PMID21609780
PMCPMC3148425
OpenAlexW2016146446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.