ArticleCell communication and signaling : CCS2011
LiCl induces TNF-α and FasL production, thereby stimulating apoptosis in cancer cells.
Article in Cell communication and signaling : CCS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Lithium-Induced Modulation of Proliferation and Apoptosis in an In Vitro Model of Colorectal Cancer.International journal of molecular sciences · 2025Article
- Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells.Apoptosis : an international journal on programmed cell death · 2023Article
- Insights into intestinal regeneration signaling mechanisms.Developmental biology · 2020Article
- 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer.Scientific reports · 2019Article
- The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster.Frontiers in genetics · 2019Article
- Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner.Journal of biomedical science · 2017Article
- Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells.Frontiers in pharmacology · 2017Article
- Article
- Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis.International journal of molecular sciences · 2016Article
- Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells.Scientific reports · 2016Article
- Article
- Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β.Molecular biology reports · 2014Article
- Lithium chloride induces TNFα in mouse macrophages via MEK-ERK-dependent pathway.Journal of cellular biochemistry · 2014Article
- Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin.The Journal of biological chemistry · 2013Article
- Proliferation rate of somatic cells affects reprogramming efficiency.The Journal of biological chemistry · 2013Article
- Lithium inhibits tumorigenic potential of PDA cells through targeting hedgehog-GLI signaling pathway.PloS one · 2013Article
- Selective cytotoxicity of PAMAM G5 core--PAMAM G2.5 shell tecto-dendrimers on melanoma cells.International journal of nanomedicine · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of cancer in patients with neurological diseases, who have been treated with LiCl, is below average. LiCl is a well-established inhibitor of Glycogen synthase kinase-3, a kinase that controls several cellular processes, among which is the degradation of the tumour suppressor protein p53. We therefore wondered whether LiCl induces p53-dependent cell death in cancer cell lines and experimental tumours.
resultsHere we show that LiCl induces apoptosis of tumour cells both in vitro and in vivo. Cell death was accompanied by cleavage of PARP and Caspases-3, -8 and -10. LiCl-induced cell death was not dependent on p53, but was augmented by its presence. Treatment of tumour cells with LiCl strongly increased TNF-α and FasL expression. Inhibition of TNF-α induction using siRNA or inhibition of FasL binding to its receptor by the Nok-1 antibody potently reduced LiCl-dependent cleavage of Caspase-3 and increased cell survival. Treatment of xenografted rats with LiCl strongly reduced tumour growth.
conclusionsInduction of cell death by LiCl supports the notion that GSK-3 may represent a promising target for cancer therapy. LiCl-induced cell death is largely independent of p53 and mediated by the release of TNF-α and FasL.Key words: LiCl, TNF-α, FasL, apoptosis, GSK-3, FasL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.