ArticleJournal of cellular and molecular medicine2011
Identification of telocytes in skeletal muscle interstitium: implication for muscle regeneration.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
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Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.
- A Detailed Systematic Review on Retinal Image Segmentation Methods.Journal of digital imaging · 2022Pooled it
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Myotendinous junction: a microenvironment favorable for short-term adaptations to resistance training following gastrocnemius muscle atrophy.Frontiers in physiology · 2025Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- A transmission electron microscopy investigation suggests that telocytes, skeletal muscles, myoblasts, and stem cells in common carp (Cyprinus carpio) respond to salinity challenges.BMC veterinary research · 2024Article
- A cellular regulator of the niche: telocyte.Tissue barriers · 2023Review
- Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands.International journal of molecular sciences · 2023Article
- Identification and protective role of CD34Histochemistry and cell biology · 2023Article
- Extracellular Vesicle MicroRNA in the Kidney.Comprehensive Physiology · 2023Article
- Delimiting CD34+ Stromal Cells/Telocytes Are Resident Mesenchymal Cells That Participate in Neovessel Formation in Skin Kaposi Sarcoma.International journal of molecular sciences · 2023Article
- Comparison of the Behavior of Perivascular Cells (Pericytes and CD34+ Stromal Cell/Telocytes) in Sprouting and Intussusceptive Angiogenesis.International journal of molecular sciences · 2022Review
- Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications.Life (Basel, Switzerland) · 2022Review
- 3D in vitro Models of Pathological Skeletal Muscle: Which Cells and Scaffolds to Elect?Frontiers in bioengineering and biotechnology · 2022Review
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Telocytes in the human ascending aorta: Characterization and exosome-related KLF-4/VEGF-A expression.Journal of cellular and molecular medicine · 2021Article
- Morphological Evidence of Telocytes in Skeletal Muscle Interstitium of Exercised and Sedentary Rodents.Biomedicines · 2021Article
- Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.International journal of molecular sciences · 2021Review
- Aquatic Training after Joint Immobilization in Rats Promotes Adaptations in Myotendinous Junctions.International journal of molecular sciences · 2021Article
- Bone Marrow-Mesenchymal Stromal Cell Secretome as Conditioned Medium Relieves Experimental Skeletal Muscle Damage Induced by Ex Vivo Eccentric Contraction.International journal of molecular sciences · 2021Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle interstitium is crucial for regulation of blood flow, passage of substances from capillaries to myocytes and muscle regeneration. We show here, probably, for the first time, the presence of telocytes (TCs), a peculiar type of interstitial (stromal) cells, in rat, mouse and human skeletal muscle. TC features include (as already described in other tissues) a small cell body and very long and thin cell prolongations-telopodes (Tps) with moniliform appearance, dichotomous branching and 3D-network distribution. Transmission electron microscopy (TEM) revealed close vicinity of Tps with nerve endings, capillaries, satellite cells and myocytes, suggesting a TC role in intercellular signalling (via shed vesicles or exosomes). In situ immunolabelling showed that skeletal muscle TCs express c-kit, caveolin-1 and secrete VEGF. The same phenotypic profile was demonstrated in cell cultures. These markers and TEM data differentiate TCs from both satellite cells (e.g. TCs are Pax7 negative) and fibroblasts (which are c-kit negative). We also described non-satellite (resident) progenitor cell niche. In culture, TCs (but not satellite cells) emerge from muscle explants and form networks suggesting a key role in muscle regeneration and repair, at least after trauma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.