ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2011
Bilirubin levels predict malignancy in patients with obstructive jaundice.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 55 citations in OpenAlex.
- Integrating Etiological Insights With Machine Learning for Precision Diagnosis of Obstructive Jaundice: Findings From a High-Volume Center.Clinical and translational gastroenterology · 2025Observational
- A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice.International journal of general medicine · 2024Article
- A machine learning-based predictive model for biliary stricture attributable to malignant tumors: a dual-center retrospective study.Frontiers in oncology · 2024Article
- Development of a Predictive Model for Common Bile Duct Stones in Patients With Clinical Suspicion of Choledocholithiasis: A Cohort Study.Gastroenterology research · 2022Article
- Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma.Liver cancer · 2022Article
- Evaluation of the American Society of Gastrointestinal Endoscopy 2019 and the European Society of Gastrointestinal Endoscopy guidelines' performances for choledocholithiasis prediction in clinically suspected patients: A retrospective cohort study.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Article
- Importance of Bile Composition for Diagnosis of Biliary Obstructions.Molecules (Basel, Switzerland) · 2021Article
- Tips and tricks for the diagnosis and management of biliary stenosis-state of the art review.World journal of gastrointestinal endoscopy · 2021Review
- Diagnostic Process Using Endoscopy for Biliary Strictures: A Narrative Review.Journal of clinical medicine · 2021Review
- Predicting Malignancy of Biliary Stricture with a Nomogram in Patients with a Non-Malignant Endoscopic Tissue Diagnosis: A Retrospective Study.Cancer management and research · 2021Article
- Radiographic Features and Clinical Factor for Preoperative Prediction in the Bulging Duodenal Papilla With Malignancy.Frontiers in oncology · 2021Article
- The Diagnostic Dilemma of Malignant Biliary Strictures.Diagnostics (Basel, Switzerland) · 2020Review
- Early Diagnosis And Management Of Malignant Distal Biliary Obstruction: A Review On Current Recommendations And Guidelines.Clinical and experimental gastroenterology · 2019Review
- Surface-immobilized and self-shaped DNA hydrogels and their application in biosensing.Chemical science · 2018Article
- Differential diagnostic roles of the serum CA19-9, total bilirubin (TBIL) and the ratio of CA19-9 to TBIL for benign and malignant.Journal of Cancer · 2018Article
- Malignant biliary strictures in patients with a normal bilirubin and/or normal liver enzymes.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- Total bilirubin is a good discriminator between benign and malignant biliary strictures.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Article
- Diagnostic and predictive ability of hyperbilirubinemia severity in cats: A multicenter retrospective study.Journal of veterinary internal medicineArticle
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferentiating between benign and malignant causes of obstructive jaundice can be challenging, even with the advanced imaging and endoscopic techniques currently available. In patients with obstructive jaundice, the predictive accuracy of bilirubin levels at presentation was examined in order to determine whether such data could be used to differentiate between malignant and benign disease.
methodsA total of 1,026 patients with obstructive jaundice were identified. Patients were divided into benign and malignant groups. The benign patients were subgrouped into those with choledocholithiasis and those with inflammatory strictures of the biliary tree. Bilirubin levels at presentation and other demographic data were obtained from case records.
resultsArea under the curve (AUC) values for bilirubin as a predictor of malignancy were highly significant for all benign presentations and for those with benign biliary strictures (AUC: 0.8 for both groups; P < 0.001). A bilirubin level > 100 µmol/l was determined to provide the optimum sensitivity and specificity for malignancy in all patients and in those without choledocholithiasis (71.9% and 86.9%, 71.9% and 88.0%, respectively). The application of a bilirubin level > 250 µmol/l achieved specificities of 97.1% and 98.0% in each subgroup of patients, respectively.
conclusionsIn patients with obstructive jaundice, bilirubin levels in isolation represent an important tool for discriminating between benign and malignant underlying causes.
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