ArticleJournal of proteome research2011
Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors associated with interstitial lung disease among patients with idiopathic inflammatory myopathies.Rheumatology (Oxford, England) · 2026Pooled it
- The role of protein glycosylation in muscle diseases.Molecular biology reports · 2022Review
- Immunoglobulin G N-glycan Biomarkers for Autoimmune Diseases: Current State and a Glycoinformatics Perspective.International journal of molecular sciences · 2022Review
- Glycosylation of Anti-Thyroglobulin IgG1 and IgG4 Subclasses in Thyroid Diseases.European thyroid journal · 2021Article
- Immunoglobulin G Glycosylation in Diseases.Experientia supplementum (2012) · 2021Article
- Immunoglobulin G Glycosylation Changes in Aging and Other Inflammatory Conditions.Experientia supplementum (2012) · 2021Article
- Article
- Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.Frontiers in physiology · 2019Article
- Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies.Scientific reports · 2018Article
- Article
- Potential of glycosylation research in graft versus host disease after allogeneic hematopoietic stem cell transplantation.Biochimica et biophysica acta · 2016Review
- Human plasma protein N-glycosylation.Glycoconjugate journal · 2016Review
- A case for protein-level and site-level specificity in glycoproteomic studies of disease.Glycoconjugate journal · 2016Review
- Disease-specific IgG Fc N-glycosylation as personalized biomarkers to differentiate gastric cancer from benign gastric diseases.Scientific reports · 2016Article
- Article
- Changes in anti-thyroglobulin IgG glycosylation patterns in Hashimoto's thyroiditis patients.The Journal of clinical endocrinology and metabolism · 2015Article
- Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G rapidly appears in sera of animals following antigen exposure.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Many autoimmune conditions are believed to result from chronic inflammation as a consequence of the interaction of genetic and environmental factors in susceptible individuals. One common feature in some autoimmune diseases is the decrease in terminal galactosylation of the constant region N-glycan of the total plasma immunoglobulin. To determine whether a similar pattern is characteristic for the autoimmune disorder myositis, we analyzed the antibody subclass specific glycosylation in patients with myositis, their asymptomatic siblings, and healthy unrelated age- and sex-matched controls. The antibody subclass specific glycosylation was determined from the LC-MS analyses of the IgG glycopeptides generated by trypsin digestion of the antibody heavy chain. The glycosylation profiles of the IgG subclasses were determined relative to the total abundance of all glycoforms. We found elevated amounts of glycoforms lacking terminal galactose in myositis patients. Pairwise statistical analyses reveals that galactosylation is statistically different between the myositis patients and control groups. Furthermore, the trend analysis for glycosylation indicates a pattern of decreasing galactosylation in the order controls ≥ siblings ≥ myositis patients, suggesting the existence of a genetic, immune-related predisposition in the group of asymptomatic siblings that can be detected before the onset of clinical symptoms at the level of plasma proteins.
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