ArticleStem cells (Dayton, Ohio)2011
Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.
Article in Stem cells (Dayton, Ohio), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Neuroprotective effect of mesenchymal stem cell-derived miR-143-3p on dopaminergic neurons via the TLR3/NF-κB/p53 signaling pathway.Stem cell research & therapy · 2026Article
- Cryopreservable dopaminergic progenitors derived from human iPSCs with accelerated loss of pluripotency and early functional restoration in Parkinsonian rats.NPJ Parkinson's disease · 2026Article
- Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease.Theranostics · 2023Article
- The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.Neuronal signaling · 2021Review
- Article
- Review
- Induced pluripotent stem cells in rat models of Parkinson's disease: A systematic review and meta-analysis.Biomedical reports · 2018Article
- The role of nonhuman primate models in the development of cell-based therapies for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases.Biology of reproduction · 2017Review
- Establishment of a translational endothelial cell model using directed differentiation of induced pluripotent stem cells from Cynomolgus monkey.Scientific reports · 2016Article
- Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.Nature · 2016Article
- Induced pluripotent stem cells and Parkinson's disease: modelling and treatment.Cell proliferation · 2016Review
- iPS cell transplantation for traumatic spinal cord injury.Current stem cell research & therapy · 2016Review
- A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.eLife · 2015Article
- Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.Cell stem cell · 2015Article
- Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration.Stem cells translational medicine · 2015Review
- The State of Play with iPSCs and Spinal Cord Injury Models.Journal of clinical medicine · 2015Article
- Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.Stem cells (Dayton, Ohio) · 2013Article
- Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models.Stem cells and cloning : advances and applications · 2013Review
- Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.Cell reports · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Immune rejection and risk of tumor formation are perhaps the greatest hurdles in the field of stem cell transplantation. Here, we report the generation of several lines of induced pluripotent stem cells (iPSCs) from cynomolgus macaque (CM) skin fibroblasts carrying specific major histocompatibility complex (MHC) haplotypes. To develop a collection of MHC-matched iPSCs, we genotyped the MHC locus of 25 CMs by microsatellite polymerase chain reaction analysis. Using retroviral infection of dermal skin fibroblasts, we generated several CM-iPSC lines carrying different haplotypes. We characterized the immunological properties of CM-iPSCs and demonstrated that CM-iPSCs can be induced to differentiate in vitro along specific neuronal populations, such as midbrain dopaminergic (DA) neurons. Midbrain-like DA neurons generated from CM-iPSCs integrated into the striatum of a rodent model of Parkinson's disease and promoted behavioral recovery. Importantly, neither tumor formation nor inflammatory reactions were observed in the transplanted animals up to 6 months after transplantation. We believe that the generation and characterization of such histocompatible iPSCs will allow the preclinical validation of safety and efficacy of iPSCs for neurodegenerative diseases and several other human conditions in the field of regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.