ArticleMagnetic resonance in medicine2011
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed.
- MRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers.Scientific reports · 2022Article
- A Frequency-Selective pH-Responsive paraCEST Agent.Angewandte Chemie (International ed. in English) · 2020Article
- Binding site exchange kinetics revealed through efficient spin-spin dephasing of hyperpolarizedChemical science · 2020Article
- Molecular Sensing with Host Systems for HyperpolarizedMolecules (Basel, Switzerland) · 2020Review
- Detecting acid phosphatase enzymatic activity with phenol as a chemical exchange saturation transfer magnetic resonance imaging contrast agent (PhenolCEST MRI).Biosensors & bioelectronics · 2019Article
- Triazoles as TChemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Z-spectrum appearance and interpretation in the presence of fat: Influence of acquisition parameters.Magnetic resonance in medicine · 2018Article
- Phenols as Diamagnetic TChemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- Lanthanide-Based TAngewandte Chemie (International ed. in English) · 2017Article
- A biomarker-responsive TMagnetic resonance in medicine · 2017Article
- Oxidation-Responsive, EuACS omega · 2017Article
- Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection.Annual review of analytical chemistry (Palo Alto, Calif.) · 2016Review
- Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
- Gd3TCAS2: An Aquated Gd(3+)-Thiacalix[4]arene Sandwich Cluster with Extremely Slow Ligand Substitution Kinetics.Inorganic chemistry · 2016Article
- A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.Angewandte Chemie (International ed. in English) · 2015Article
- Double agents and secret agents: the emerging fields of exogenous chemical exchange saturation transfer and TResearch and reports in nuclear medicine · 2015Article
- Natural D-glucose as a biodegradable MRI relaxation agent.Magnetic resonance in medicine · 2014Article
- Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging.Nature chemistry · 2014Article
- Maximizing T2-exchange in Dy(3+)DOTA-(amide)X chelates: fine-tuning the water molecule exchange rate for enhanced T2 contrast in MRI.Magnetic resonance in medicine · 2014Article
- Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents.NMR in biomedicine · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Exchange of water molecules between the frequency-shifted inner-sphere of a paramagnetic lanthanide ion and aqueous solvent can shorten the T(2) of bulk water protons. The magnitude of the line-broadening T(2) exchange (T(2exch)) is determined by the lanthanide concentration, the chemical shift of the exchanging water molecule, and the rate of water exchange between the two pools. A large T(2exch) contribution to the water linewidth was initially observed in experiments involving Eu(3+)-based paramagnetic chemical exchange saturation transfer agents in vivo at 9.4 T. Further in vitro and in vivo experiments using six different Eu(3+) complexes having water exchange rates ranging from zero (no exchange) to 5 × 10(6) s(-1) (fast exchange) were performed. The results showed that the exchange relaxivity (r(2exch)) is small for complexes having either very fast or very slow exchange, but reaches a well-defined maximum for complexes with intermediate water exchange rates. These experimental results were verified by Bloch simulations for two site exchange. This new class of T(2exch) agent could prove useful in the design of responsive MRI contrast agents for molecular imaging of biological processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.