ArticleMolecular biology reports2012
Association of SCD1 and DGAT1 SNPs with the intramuscular fat traits in Chinese Simmental cattle and their distribution in eight Chinese cattle breeds.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed, 40 citations in OpenAlex.
- Identification of miR-320d as a Negative Regulator of Proliferation and Fatty Acid Synthesis via Targeting SCD in Ovine Tail Preadipocytes.Animals : an open access journal from MDPI · 2026Article
- Expression of miRNA in the Semitendinosus Muscle of Cattle Breeds with Varying Intramuscular Fat Deposition.Genes · 2025Article
- Genetic Markers Related to Meat Quality Properties in Fattened HF and HF x Charolaise Steers.Genes · 2024Article
- Polymorphisms at Candidate Genes for Fat Content and Fatty Acids Composition: Effects on Sheep Milk Production and Fatty Acid Profile Using Two Dietary Supplementations.Animals : an open access journal from MDPI · 2023Article
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- Associations between gene polymorphisms and selected meat traits in cattle - A review.Animal bioscience · 2021Article
- The effect of an energy additive on the metabolism of cattle.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Association of DGAT1 With Cattle, Buffalo, Goat, and Sheep Milk and Meat Production Traits.Frontiers in veterinary science · 2021Review
- Transcriptomic Analysis Identifies Candidate Genes Related to Intramuscular Fat Deposition and Fatty Acid Composition in the Breast Muscle of Squabs (Columba).G3 (Bethesda, Md.) · 2016Article
- A Review of Selected Genes with Known Effects on Performance and Health of Cattle.Frontiers in veterinary science · 2016Review
- An interpretive review of selective sweep studies in Bos taurus cattle populations: identification of unique and shared selection signals across breeds.Frontiers in genetics · 2015Review
- Molecular cloning, tissue expression and SNP analysis in the goat nerve growth factor gene.Molecular biology reports · 2013Article
- Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle.Molecular biology reports · 2013Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramuscular fat (IMF) is a key parameter for evaluation of nutritional quality of beef, with its endogenous synthesis regulated by stearoyl CoA desaturase (SCD1) and diacylglycerol-acyl transferase 1 (DGAT1) genes in cattle. The object of this research was to evaluate the effect of SCD1 and DGAT1 polymorphisms on IMF trait in beef cattle and to estimate the frequency distribution of SNPs in the two genes in Chinese cattle populations. The SCD1 and DGAT1 polymorphisms were detected by PCR-single strand conformation polymorphism (PCR-SSCP) method in Chinese Simmental cattle and their associations with IMF traits were analyzed using the general linear model (GLM). The frequency distribution of SNPs in SCD1 and DGAT1 genes were detected by PCR-SSCP method and analyzed in seven other cattle populations. The results showed significant associations of SNPs SCD1-878, SCD1-762, and DGAT1 10433 and 10434 with IMF (%) and shearing force values (SFV; kg) in Chinese Simmental cattle. A haplotype combining SCD1-878C, SCD1-762T, and DGAT1 10433 and 10434-GC had the highest IMF, marbling score and shearing force. The polymorphic investigation indicated that the frequency of SCD1-878C or SCD1-762T was significantly higher in Chinese southern cattle (Leiqiong, Yunnan High pump, BMY or Minnan Cattle) than in Chinese northern cattle (Chinese Simmental, Luxi Cattle, Bohai Black or Chinese Holstein), while the frequency of DGAT1 10433 and 10434-GC in Chinese indigenous breed (Leiqiong, Yunnan High pump, BMY, Luxi Cattle, Bohai Black, or Minnan Cattle) was significantly lower than breeds with imported blood (Chinese Simmental or Chinese Holstein). These findings demonstrated that both the SCD1 and DGAT1 SNPs were prospect genetic markers for IMF traits, and the SCD1 SNPs could be used as a genetic marker for southern or northern blood in Chinese cattle.
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