ArticleBreast cancer research and treatment2011
Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.
Article in Breast cancer research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Discovery of differentially expressed novel miRNAs in breast normal cells and their putative targets.Molecular and cellular biochemistry · 2023Article
- Role of motor proteins in human cancers.Saudi journal of biological sciences · 2022Review
- Comprehensive analysis of transcriptome characteristics and identification ofFrontiers in genetics · 2022Article
- The importance of CDC27 in cancer: molecular pathology and clinical aspects.Cancer cell international · 2021Review
- SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.EMBO reports · 2020Article
- Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival.Scientific reports · 2020Article
- The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease.Cellular and molecular life sciences : CMLS · 2019Review
- Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion.Journal of extracellular vesicles · 2018Article
- Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression.Journal of cell science · 2016Article
- Evaluation of a newly discovered breast cancer susceptibility locus at 6q25.1 in Iranian Azari-Turkish women.Contemporary oncology (Poznan, Poland) · 2016Article
- Association between polymorphisms in cdc27 and breast cancer in a Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- MiR-27a modulates radiosensitivity of triple-negative breast cancer (TNBC) cells by targeting CDC27.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells.BMC cancer · 2013Article
- Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.Nucleic acids research · 2013Article
- The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.PloS one · 2013Article
- Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy.Genes & cancer · 2013Article
- The Tousled-Like Kinases as Guardians of Genome Integrity.ISRN molecular biology · 2012Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. Specifically, disregulation and somatic mutation of mitotic regulators has been observed in human cancers, and overexpression of mitotic regulators is common in aggressive and late stage tumors. However, the role of germline variation in mitotic pathways and risk of cancer is not well understood. We tested 1,084 haplotype-tagging and functional variants from 164 genes in mitotic regulatory pathways in 791 Caucasian women with breast cancer and 843 healthy controls for association with risk of overall and high grade breast cancer. Sixty-one single nucleotide polymorphisms (SNPs) from 40 genes were associated (P < 0.05) with risk of breast cancer in a log-additive model. In addition, 60 SNPs were associated (P < 0.05) with risk of high grade breast cancer. However, none of these associations were significant after Bonferroni correction for multiple testing. In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both. Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk.
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