ArticleClinical oral investigations2012
Efficacy of taurolidine against periodontopathic species--an in vitro study.
Article in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Bacterial sensitivity to chlorhexidine and povidone-iodine antiseptics over time: a systematic review and meta-analysis of human-derived data.Scientific reports · 2023Pooled it
- Taurolidine as an effective and biocompatible additive for plaque-removing techniques on implant surfaces.Clinical oral investigations · 2015Trial
- Effect of a bacterial glutaminyl cyclase inhibitor on multi-species-biofilms.Frontiers in oral health · 2025Article
- Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats.Biomolecules & therapeutics · 2025Article
- The European TauroPace™ Registry.Methods and protocols · 2023Article
- Antimicrobial efficacy of chlorine agents against selected oral pathogens.Clinical oral investigations · 2023Article
- Taurolidine Acts on Bacterial Virulence Factors and Does Not Induce Resistance in Periodontitis-Associated Bacteria-An In-Vitro Study.Antibiotics (Basel, Switzerland) · 2020Article
- Activity of taurolidine gels on ex vivo periodontal biofilm.Clinical oral investigations · 2018Article
- Effect of mouthwashes on the composition and metabolic activity of oral biofilms grown in vitro.Clinical oral investigations · 2017Article
- In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis.Clinical oral investigations · 2016Article
- In vitro activity of taurolidine gel on bacteria associated with periodontitis.Clinical oral investigations · 2016Article
- Article
- Evaluation of the efficacy of taurine as an antioxidant in the management of patients with chronic periodontitis.Dental research journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antimicrobial effect of taurolidine was tested against periodontopathic species in comparison to chlorhexidine digluconate in the presence or absence of serum. Minimal inhibitory concentrations (MIC), microbiocidal concentrations (MBC), as well as killing were determined against 32 different microbial strains including 3 Porphyromonas gingivalis, 3 Aggregatibacter actinomycetemcomitans, and 15 potentially superinfecting species with and without 25% v/v human serum. The MIC(50) of taurolidine against the tested microbial strains was 0.025% and the MIC(90) 0.05%. The respective values for the MBCs were 0.05% and 0.1%. Addition of 25% serum (heat-inactivated) did not change the MIC and MBC values of taurolidine. In contrast, MICs and MBCs of chlorhexidine (CHX) increased by two steps after addition of serum. Taurolidine killed microorganisms in a concentration and time-dependent manner, the killing rate of 1.6% taurolidine was 99.08% ± 2.27% in mean after 2 h. Again, killing activity of taurolidine was not affected if serum was added, whereas addition of inactivated serum clearly reduced the killing rate of all selected bacterial strains by CHX. Therefore, taurolidine possesses antimicrobial properties which are not reduced in the presence of serum as a main component in gingival crevicular fluid and wound fluid. Taurolidine may have potential as an antimicrobial agent in non-surgical and surgical periodontal treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.