ArticleWorld journal of gastrointestinal pathophysiology2011
MAPKs represent novel therapeutic targets for gastrointestinal motility disorders.
Article in World journal of gastrointestinal pathophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Zuojin Pill enhances gastrointestinal motility by modulating the pacemaker potentials in interstitial cells of Cajal through multiple signaling pathways.International journal of medical sciences · 2024Article
- Comparison of laxative effects of fermented soybeans (Nutrition research and practice · 2022Article
- Effects of black garlic on the pacemaker potentials of interstitial cells of Cajal in murine small intestineAnimal cells and systems · 2022Article
- Grape seed powder increases gastrointestinal motility.International journal of medical sciences · 2022Article
- Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of patients suffering from symptoms associated with gastrointestinal (GI) motility disorders is on the rise. GI motility disorders are accompanied by alteration of gastrointestinal smooth muscle functions. Currently available drugs, which can directly affect gastrointestinal smooth muscle and restore altered smooth muscle contractility to normal, are not satisfactory for treating patients with GI motility disorders. We have recently shown that ERK1/2 and p38MAPK signaling pathways play an important role in the contractile response not only of normal intestinal smooth muscle but also of inflamed intestinal smooth muscle. Here we discuss the possibility that ERK1/2 and p38MAPK signaling pathways represent ideal targets for generation of novel therapeutics for patients with GI motility disorders.
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