Evidence map›Paper›PMID 21607139›Full record

ArticleWorld journal of gastrointestinal pathophysiology2010

Aberrant DNA methylation profile in cholangiocarcinoma.

Li Huang, Gabriel Frampton, Li-Jian Liang, Sharon Demorrow

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastrointestinal pathophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. MicroRNAs in biliary diseases.World journal of gastroenterology · 2012
    Review
  5. Genetic profiling of intrahepatic cholangiocarcinoma.Current opinion in gastroenterology · 2012
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Li HuangLi Huang, Gabriel Frampton, Sharon DeMorrow, Department of Internal Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76504, United States.
Gabriel Frampton
Li-Jian Liang
Sharon Demorrow
Temple College · US

Funding

Endocannabinoid Regulation of Cholangiocarcinoma Cell GrowthK01DK078532 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DEMORROW, SHARON · 2007 to 2011
$697k
NIDDK NIH HHS K01 DK078532
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is a notoriously lethal epithelial cancer originating from the biliary system. As radical resection offers a poor success rate and limited effective adjuvant modalities exist in its advanced stage, the disease leads to a fairly poor prognosis. As the incidence of CCA is increasing, although the mortality rate remains stable, and few other definite etiologies have yet to be established, renewing our knowledge of its fundamental carcinogenesis is advisable. The latest advances in molecular carcinogenesis have highlighted the roles of epigenetic perturbations and cancer-related inflammation in CCA. This review focuses on the reciprocal effects between aberrant DNA methylation and inflammatory microenvironment in CCA.

Indexed as

Cancer-related inflammationCholangiocarcinomaDNA methylationEpigenomeMicroenvironment

Identifiers

PMID21607139
PMCPMC3097943
OpenAlexW2036870108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.