ArticleFrontiers in pharmacology2010
Neuropeptides in the gonads: from evolution to pharmacology.
Article in Frontiers in pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Basic biology is not just "for the birds": how avian studies have informed us about vertebrate reproduction.F&S reports · 2025Article
- Impact of stress on male fertility: role of gonadotropin inhibitory hormone.Frontiers in endocrinology · 2023Review
- Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction.Frontiers in veterinary science · 2022Review
- Advances in Reproductive Endocrinology and Neuroendocrine Research Using Catfish Models.Cells · 2021Review
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination.PLoS genetics · 2021Article
- Kisspeptin and Testicular Function-Is it Necessary?International journal of molecular sciences · 2020Review
- Article
- Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction.Frontiers in endocrinology · 2019Review
- The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction.Iranian journal of basic medical sciences · 2018Review
- Seasonal Reproduction in Vertebrates: Melatonin Synthesis, Binding, and Functionality Using Tinbergen's Four Questions.Molecules (Basel, Switzerland) · 2018Review
- Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?Iranian journal of basic medical sciences · 2017Review
- Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals.Frontiers in endocrinology · 2017Review
- Gonads and the evolution of hormonal phenotypes.Integrative and comparative biology · 2016Article
- Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction.Journal of neuroendocrinology · 2016Review
- Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models.Frontiers in endocrinology · 2015Review
- Expression analysis of gnrh1 and gnrhr1 in spermatogenic cells of rat.International journal of endocrinology · 2015Article
- Review: regulatory mechanisms of gonadotropin-inhibitory hormone (GnIH) synthesis and release in photoperiodic animals.Frontiers in neuroscience · 2013Article
- The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent.PeerJ · 2013Article
- GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate gonads are the sites of synthesis and binding of many peptides that were initially classified as neuropeptides. These gonadal neuropeptide systems are neither well understood in isolation, nor in their interactions with other neuropeptide systems. Further, our knowledge of the control of these gonadal neuropeptides by peripheral hormones that bind to the gonads, and which themselves are under regulation by true neuropeptide systems from the hypothalamus, is relatively meager. This review discusses the existence of a variety of neuropeptides and their receptors which have been discovered in vertebrate gonads, and the possible way in which such systems could have evolved. We then focus on two key neuropeptides for regulation of the hypothalamo-pituitary-gonadal axis: gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH). Comparative studies have provided us with a degree of understanding as to how a gonadal GnRH system might have evolved, and they have been responsible for the discovery of GnIH and its gonadal counterpart. We attempt to highlight what is known about these two key gonadal neuropeptides, how their actions differ from their hypothalamic counterparts, and how we might learn from comparative studies of them and other gonadal neuropeptides in terms of pharmacology, reproductive physiology and evolutionary biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.